You can shoot long esters E3D and be perfectly on point. Sust and Omna should be shot EOD. EOD!.. EOD!!!
I think pharmacokinetics and pharmacodynamics would disagree with you on the need for such frequent dosing considering rather large therapeutic index of testosterone and other AAS.
If Sust was only containing the two short acting esters, you could go for EOD because blood levels would dip 25% by 48 hours vs waiting until it reached 50% concentration by day 4 or 5.
However, they presence of esters have twice and thrice the half-life of the shorter ones, you would really not need EOD, hell, once a week would get you a drop of 25 % of the long acting ester and nearing 50% of isocaproate (of course the 2 short acting ones would be down 75%).
Still, last time I check the Sust Amps ‘‘contain’’ more than 1.5 times more longer esters than shorter ones.
Personally, I think its bad combining to put short acting esters with long acting ones, because like it was said above, to ensure stable levels of the short one you would go EOD, but then you loose the adavantage that the long acting ones provide in not having to go EOD or even E(3-4-5)D.
However, per medical reasons, it allows for one prescription and for rapid gains (anabolic and androgenic) and since patient suck at being complient you understand the purposes behing it but still, for HRT purposes I question the real usefulness of this time-release stack since you go for injections E2W or more in some instances.
Overall, you could inject EOD until you’ve reached steady state levels of the longest acting ester which would be between 45 to 60 days after which it probably is not worth it from an inconvenieance/benefit perspective.
Like it was said above a given quantity of drug spread out on multiple dose or through Extended Release methods will reduce side effects, simple pharmacokinetics.