Cy Willson - The How’s and Why’s of Frontloading
Frontloading is the practice of taking a larger amount of a given drug in order to elevate blood levels rapidly in order to achieve the desired effect at a more rapid pace.
So, let’s say you have androgen X and you plan on using 500 mg weekly. The half-life of this drug is around seven days. Well, after a week, you have approximately 250 mg in your bloodstream. So, at the moment of the next injection, you have ~750 mg in your bloodstream. Now, which week is going to yield better results, the first week or the second and thereafter? Of course, all of you will say the second week since the amount in the bloodstream is higher.
So, the reasoning here is that the first week is essentially useless since your blood levels aren’t exactly at an optimal level. So instead, you could choose to frontload with 1,500 mg during the first week. After a week, you have blood levels of ~750 mg. So now the first week wasn’t such a “waste.” Essentially, what it comes down to is that you’re accelerating the accumulation of the material in the bloodstream so that you don’t waste that first week or two being at sub-optimal levels.
The drugs where frontloading really isn’t as advantageous would be those with an extremely short half-life. So, if drug X has a half-life of 12 to 24 hours and you plan on injecting 500 mg per week, you’ll only have a small amount (a few mg) in the bloodstream after a week has passed. Now, this changes when you consider the fact that guys are smart enough to perform daily or every other day injections. Even so, a short half-life just doesn’t provide for blood levels to stay at a consistently high level, so there isn’t as much of a reason to frontload. In my opinion, if the half-life is shorter than 72 hours, it isn’t worth frontloading.