T Nation

Supplementing with Natural SERMs.


#1

Aromatase inhibitors like Arimidex will knock circulating estrogen down in a man's body. Many side-effects will arise when estrogen is excessively low; such as low libido, brain fog, etc.
Athletes use drugs like Clomiphene and Tamoxifen as SERMs to occupy the estrogen receptor and impart "selective" estrogen effects- the problem is, drugs like Clomiphene can cause depression in some people, which is due to it's estrogen-receptor stimulation in the brain.

My question is, has anyone here tried a natural SERM such as Panax Ginseng while on Arimidex to keep some positive estrogen activity? It should boost libido and mental clarity, and it should also work better than Clomiphene since it would't cause depression.


#2

Clomiphene/Clomid only has those negative effects for some guys. I suggest Nolvadex because it does the same thing and does not have those negative effects. Taking a SERM will increase E2 levels, not decrease. SERM’s are not part of mainstream TRT!

The idea with Arimidex/anastrozole is to modulate E2 levels to the lower 20’s and there are not any negative effects from that. The way that you make your points is alarmist. With lab work and other advice here in the stickies, problems do not occur.

So you don’t have to think about the Arimidex workarounds that you suggest, simply try 1mg/week in divided doses and do lab work. Reduce to 1/4mg per week if you are an anastrozole over-responder. DO NOT read about Arimidex side effects from women taking 1mg per day who get E2=zero, simply misleading for you. Most guys here on TRT use anastrozole.

There are 7 stickies in this forum, start reading “advice for new guys”.


#3

Makes sense. As long as you go about it in a scientific manner, one’s Arimidex use should not cause those side effects in the first place.