To give a brief (which in my case always means a LONG and drawn out) answer to the original question: Yes, it's a great idea to try taking mid-workout supplements to avoid nutrient depletion IF your workouts are longer than 45 min. My workouts avg 1hr 15min. Sometimes 1.5hr.
And I always drink an intra-workout shake with water, 25g whey, BCAA, and gatorade powder (keeps insulin coming so cortisol doesn't, but you could replace this with dextrose or other sugar). This, combined with a pre-workout stim (1MR, black powder, jack3d, or whatev) keeps my workouts strong for the entire duration.
I usually leave feeling like I could do one more set (keeping one in the chamber). Try it out. You'll FEEL the difference. Then you don't need anyone else to tell you whether or not there's a benefit.
MAF and MODOK, you both make great points! And yes, the OP (styven.tamburo) may be a little stubborn in his opinion. But with the vague research-based "evidence" out there, it's easy to understand why he doesn't know what to believe and has to carefully filter responses. I believe the consensus has been to drink a mid-wo shake. If he's wise, he'll try it.
Otherwise he can keep doing what he's been doing, and call his thread-responders (who have been generous enough to donate their time) "stupid" and to "shut up", and continue missing out on a lot of potential muscle growth. In that case, more looks for us at the gym, and fewer for him.