T Nation

Suicidal AIs


#1

can someone explain the benifits of using a suicidal AI (class 1) such as aromasin or (class 2) such as Anastrazole, not sure what class letrozole falls into but I've heard to be cautious with it because it can hammer your E2 Into the ground.. some people don't use AIs at all because they don't get any negative side effects with not using it. Any experience with the three most common variants? Anyone like to elaborate. Just curious.. thanks guys


#2

Edit** I understand class one AIs are suicidal. But why use one over another… opinions?


#3

Aromasin in healthy men: http://press.endocrine.org/doi/full/10.1210/jc.2003-031279

Arimidex in healthy men: http://www.ncbi.nlm.nih.gov/pubmed/10902781

Femara in healthy men: http://www.eje.org/content/160/3/397.full

^according to that data, aromasin is actually the weakest at lowering estrogen. however, it works by a different mechanism, and seems to work much faster.

A-dex and Aromasin build up to stable blood levels in about a week, but Letro takes close to a month (with daily doses for all 3 compounds).

FYI, here’s a thread i made on estrogen control a while back: http://tnation.T-Nation.com/free_online_forum/sports_training_performance_bodybuilding_gear/thoughts_on_estrogen_and_gyno_management


#4

i guess the question, is how much of an AI you actually need. most guys run .25 mg-.5 mg of A-dex, EOD.

^for cost effectiveness, A-dex might be the best…

however, Aromasin is easier to come off, as it can’t really cause an estrogen rebound…


#5

[quote]cycobushmaster wrote:
i guess the question, is how much of an AI you actually need. most guys run .25 mg-.5 mg of A-dex, EOD.

^for cost effectiveness, A-dex might be the best…

however, Aromasin is easier to come off, as it can’t really cause an estrogen rebound…[/quote]

How much you need is dependant on a person to person basis. But there are standard doses recommended to start at.


#6

so I guess the answer I was looking for is that aromasin is better for preventing rebound. However if dosed smartly and appropriately Adex will very unlikely cause rebound? So either one dosed appropriately is gtg. btw that was a good thread you posted cyco regarding gyno/estrogen management


#7

[quote]Ross_AlanUSN10 wrote:
so I guess the answer I was looking for is that aromasin is better for preventing rebound. However if dosed smartly and appropriately Adex will very unlikely cause rebound? So either one dosed appropriately is gtg. btw that was a good thread you posted cyco regarding gyno/estrogen management[/quote]

yeah, i think if you tapered off A-dex or Letro then you shouldn’t expect a rebound. personally, i’ve seen a lot of guys stop using it before their ester clears (the time between the cycle and PCT) and have issues there.

i’m very conservative on estrogen, though. while low estrogen sucks, high estrogen can really causes issues with the HPTA that only an AI can solve, not to mention the other things.

i’m also of the opinion that SERMs and AIs seem to cause less side effects when taken at night, since drowsiness is a common side for most of them. i think some guys believe that their estrogen is too low, when they’re really seeing the side effect from the drug itself…


#8

Ive ran both dex, and aro in cycles.
Honestly when it comes to my symptoms (extremely gyno prone)
Aro has always been much superior for me.
I have both laying around at home just in case, I feel like dosage wise adex is effective,but as far as how my body responds aro is much better, however alot more expensive dose wise…

I usually run aro at 25mg/day because I have pretty bad gyno already from puberty. Some times I run it at 12.5/day just to make sure I am responding correctly but when I see symptoms increasing I go back to 25mg.