T Nation

Suggestion for Adjusting AI to Get E in the Right Spot?

After 8 weeks on TRT with a dosage of 210MG Test Cyp, 1.5MG Arimidex, and 1000IU HCG a week my results are as follows:

Total test: 176 to 1018 (range 264-916)

Free Test: 3.6 to 35.1 (range 8.7-25.1)

Est: 15.4 to 10 (range 7.6 - 42.6)

So I feel good but want to let my E go up as I remember feeling better when my E was higher. Should I reduce AI by .25 mg or .5mg to get it closer to the 20-25 range?

Just looking for personal opinions and experiences on what dosage worked for you. Thanks

Given that I will be speaking with my Doctor as well

Do you know if that E2 test was the sensitive assay? Labcorp code: 140244, Questlab code: 30289

It was not the sensitive test it was the Roche Eclia one. So from what I read my E is prob slightly lower than what this one states. So bascially wondering if I should lower my AI dose from 1.5 mg a week to 1.25, 1, or even less to get into the 20-25 range.

When my e2 is that low I feel like garbage. Tired, no motivation, vascularity is in the dumps. Dry skin, lips, eyes, Headache.

Don’t leave it that low for too long. Lots of nasty consequences.

How often are you injecting? You may only need a portion of what you are taking depending on how your body reacts to it. I know some guys take very small amounts (.125mg) at time of injection to control E2. You need to figure this out so you can dial it in and that’s going to require continued testing. Is this from a TRT shop? Will they help you dial in with labs etc?

I’m injecting once a week and taking AI 3x a week. I feel great on my current test dosage but felt superhuman about 3 weeks ago when i assume my E was higher as I missed a dose of ai.


Your T levels peak then drop, E2 does similar but lags a bit. Your lab results are mostly determined by lab timing and not useful.

Inject subq twice a week to get smoother T levels then the T competitive drug anastrozole can match T levels and work right.

Your lab results are not very useful. At beginning of week AI dose is too low and at end of week it is too high. Change protocol and test E2 again and it is not Est please.

Do not do labs if you have missed any doses in prior week.
Try to always do labs halfway between injections to reduce noise of lab timing.

You need to test CBC and hematocrit to see if TRT is making your blood too thick.

Please read the stickies found here: About the T Replacement Category

  • advice for new guys - need more info about you
  • things that damage your hormones
  • protocol for injections
  • finding a TRT doc

Evaluate your overall thyroid function by checking oral body temperatures as per the thyroid basics sticky. Thyroid hormone fT3 is what gets the job done and it regulates mitochondrial activity, the source of ATP which is the universal currency of cellular energy. This is part of the body’s temperature control loop. This can get messed up if you are iodine deficient. In many countries, you need to be using iodized salt. Other countries add iodine to dairy or bread.

KSman is simply a regular member on this site. Nothing more other than highly active.

I can be a bit abrupt in my replies and recommendations. I have a lot of ground to cover as this forum has become much more active in the last two years. I can’t follow threads that go deep over time. You need to respond to all of my points and requests as soon as possible before you fall off of my radar. The worse problems are guys who ignore issues re thyroid, body temperatures, history of iodized salt. Please do not piss people off saying that lab results are normal, we need lab number and ranges.

The value that you get out of this process and forum depends on your effort and performance. The bulk of your learning is reading/studying the suggested stickies.

You are getting too many threads/topics so we do not have one place to see your questions and labs with context of what had been posted by you and others in the past. Would you want your doctor to miss file your medical records?

Agree. Inject 100mg SQ twice a week. Your AI dose seems high. Going sub q I’ve eventually been able to drop the AI altogether and feel so much better with an E2 around 40!

Make small changes. I’d split the dose and cut 0.5 mg of your AI. Give it a few weeks so really judge the change.

With lab timing issues we cannot really make hard recommendations. His E2=15 from a single T shot with AI in multiple doses possibly acting in dropping T levels where AI is high relative to FT.

It may not be lower. My Quest immunoassay came back at 21 ng/mL, while the ultrasensitive LC/MS/MS done concurrently came in at 23 ng/mL.