Hi, I am suffering from post ssris sexual dysfunction syndrome for two years now. I have the following symptoms:
Blunted affect: I don’t feel almost anything. No thirst, no hunger, no joy in anything, no motivation to get out of bed, no interests, no inner world, no motivation, or goals, and can’t really relate to normal people’s problems anymore. Before this I was very social and outgoing guy who loved life.
Cognitive impairment: hard to remember and recall things, tasks that demand high cognition functionality are impossible (math for example)
Depersonalization/derealization: total loss of sense of self, don’t recognize myself in the mirror.
Libido is absolutely gone, shrinkage, discoloration of the penis, and numb penis like I have lidocaine patch on it 24/7.
Dry skin, dry eyes, dry hair, dry life.
Now, after gathering alot of information regarding how low/high E2 feels, I believe I have silenced\downregulated estrogen receptors.
I believe this is the case too for people who suffer from post aromatase syndrome, and post finasteride syndrome.
Both low/high E2 distrupt dopamine signaling- however, it seems like low e2 distrupts the signaling in a much more bold manner- people report that when crashing their E2 they don’t respond to dopaminergics anymore, it’s not the case with high E2, aswell as the fact low e2 results often in dry skin, dry eyes, emotional numbness. Those symptoms don’t speak loudly for high E2.
I don’t respond to coke, lsd, shrooms, ketamine. Drugs just won’t work without dopamine.
I would like to hear if anyone has any idea(s) how do I resentisize my response to Estrogens again? Trenbolone works partially, gives a bit more of a human feeling (since it upregulates ER-alpha to some degree) but it never feels normal, how it should be.
Those three threads led me to believe my receptors are epigentically silenced,
There is load of data shows how Estrogen receptors modulate the reward system and dopamine release, limbic system, and frontal lobes.
I played around with hormones, and ofcourse supraphiysiological levels didn’t do shit. Symptoms remaind the same. Anavar did help muscle atrophy, but did nothing to my Estrogen.
I hope some folks here have some answers or leads. Thank you!