I'm going to ruffle a few feathers with this one.
Anyone here familiar with either chemotherapy, drug design or chemistry will have some idea of what an alkylating agent is. The most ractive alkylating agents, are generally primary alkyl halides.
In industrial applications, if these types of compound are present as impurities it is considered unacceptable because they are widely known as the most potent carcinogens on the planet, since they irreversibly bind to DNA. A particularly nasty one of these agents is known as carmustine. It contains two primary alkyl chloride chains and can bind between the double helix in DNA, which, to use the correct technical terminology, FUCKS IT UP PROPER.
The sucralose molecule contains two similar primary alkyl chloride side chains of the correct molecular width to do the same. This would suggest that although short term studies in animals have been accepted, it is widely known that these are not always 100% indicative of an agents potential carcinogenicity. The molecular structure of sucralose by analogy indicates that it should be a potent carcinogen.