Correction, rodents who eat up to 2 grams of sucralose in ONE SINGLE DAY suffer DNA damage. Since sucralose does enter cells, since it is metabolised which is also confirmed by studies, if DNA damage due to alkylation occurs from one massive dose, then DNA damage through cumulative dosing over a long period of time is VERY likely. And the particular type of damage it will cause is the worst kind, since it is a most likely intercalating.
And of course something can be too polar to enter a cell, but to suggest a modified carbohydrate is too polar to enter is from my point of view retarded and so deserved a little put down. No hard feelings. If I say something retarded, feel free to put me in my place