T Nation

Stopped Converting to Estradiol. Why? B Vitamins Responsible?

Hi guys.

I’m 42. I’m on TRT with HCG and a bit of Cabergoline.

Recently my conversion to E2 suddenly stopped and my E2 stays around 33 (sensitive Labcorp values), which is low for my erections, I need E2 around 40-50. My E2 used to raise at the rate of approximately 12 points per week and I’ve taken Anastrozole when needed.

I didn’t change the TRT protocol, the only thing was that my last Pregnyl bottle was 9 months expired when I started it.

However, recently I’ve discovered that I have methylation issue as well, and after talking to a specialist I started taking:

Folate (around 2,000mg)
Methyl B12 (around 1,000mg)
Active form of B6, Pyridoxine P5P (825mg)
NAC (N-Acetyl Cysteine)
Zinc Picolinate increased from 30mg to 60mg (it has 2mg Copper so Copper increased to 4mg).

I’m aware that I can raise E2 by taking more HCG. But what hay have caused this sudden stop in estradiol conversion?

Are ANY of the above listed supplements known for lowering estradiol conversion?

Have you lost fat?

Stop all supplements and stick with your protocol. Its the only way to know. Right? Adding T is not as complicated as everyone makes it out to be. If you eat right and sunbathe, you should live to 85 with a hard dick in some very enthusiastic piece.

No, I actually gained weight during this lockdown. This was another change. Do you think it has anything to do with estradiol conversion?

Have your T levels changed at all or are they the same even with the increased weight? I assume you haven’t taken any AI in the last month or so?

Mine actually went from 73 to 49 on the same dose, kind of weird. It took about a year though for it to drop down that much.

My T level didn’t seem to change after I gained weight. Although… It’s hard to notice since it fluctuates with time of blood draw relative to time/date of T injection.

Is your line of though such that weigh gain might have increased demand for T while I didn’t increase T, and thus lowered T slowed conversion to E2?

I haven’t taken any AI for the lady 2.5 months.

Are you talking about T levels ?

More fat usually means more aromatisation, not less. The zinc could be lowering your E2, but it usually doesn’t lower it that much.

No, E2

Yes, so this is similar to my situation. Do you have any idea why that happened in your case?

No clue. My dose went from 180mg/week to 210mg/week too… and it still went down somehow. And my body fat has probably gone up if anything, so I’m really not sure how to explain it.

I’m now sure that my lower estradiol has nothing to do with B vitamins. I stopped all the B vits but my E2 still went from 40 down to 21 within 3 weeks… Have no idea why this is happening, this negatively affects my erections…

I spoke to my TRT doc about it. He said generally carbohydrates and alcohol brings E2 levels up, besides Testosterone. Actually I did cut some carbs trying to loose weight, my beer consumption also fluctuates so there’s a chance it affects my E2. Did anyone notice a correlation between carbs/alcohol and E2 levels???

ncsugrad2002 and everybody else who’s E2 went down: have you cut carbs/alcohol?

Drinking beer will absolutely increase your E2, unless you don’t have aromatase.

I surely don’t mind more beer, but it doesn’t bring my E2 up that much… Carbs is another thing - make me fat instantly.

Are there estradiol supplements? Found some Estrogen, not Estradiol:

Is it possible to supplement E2?

Anything is possible, but I’m not sure where you would get E2 exactly. Getting fat and having E2 are not the same thing, and E2 is generated where you need it when you need it, so serum test saren’t even that great of a way to know what your E2 really is.

I wonder if that’s why my sex drive used be insane when hungover

I used to have this too.

Having just read the scientific study that has come out saying mens libido is tied to aromatase it makes a lot of sense…

Lots of alcohol- increased aromatase.

Mad sex drive the following day

It could be the CHANGE in e2 also that gives you that burst of libido.

Whatever it was, I’d like it to happen again

Sure, birth control pills. Estradiol, 1-2mg \ day.

Lovely, my first doc said the same thing about testosterone. Homeostasis is a wonderful thing - but understand its broken in everyone here hence the need to fiddle with hormones.