T Nation

Stopped Converting to Estradiol. Why? B Vitamins Responsible?

T Replacement
#1

Hi guys.

I’m 42. I’m on TRT with HCG and a bit of Cabergoline.

Recently my conversion to E2 suddenly stopped and my E2 stays around 33 (sensitive Labcorp values), which is low for my erections, I need E2 around 40-50. My E2 used to raise at the rate of approximately 12 points per week and I’ve taken Anastrozole when needed.

I didn’t change the TRT protocol, the only thing was that my last Pregnyl bottle was 9 months expired when I started it.

However, recently I’ve discovered that I have methylation issue as well, and after talking to a specialist I started taking:

Folate (around 2,000mg)
Methyl B12 (around 1,000mg)
Active form of B6, Pyridoxine P5P (825mg)
Potassium
Magnesium
NAC (N-Acetyl Cysteine)
Zinc Picolinate increased from 30mg to 60mg (it has 2mg Copper so Copper increased to 4mg).

I’m aware that I can raise E2 by taking more HCG. But what hay have caused this sudden stop in estradiol conversion?

Are ANY of the above listed supplements known for lowering estradiol conversion?

#2

Have you lost fat?

#3

Stop all supplements and stick with your protocol. Its the only way to know. Right? Adding T is not as complicated as everyone makes it out to be. If you eat right and sunbathe, you should live to 85 with a hard dick in some very enthusiastic piece.

#4

No, I actually gained weight during this lockdown. This was another change. Do you think it has anything to do with estradiol conversion?

#5

Have your T levels changed at all or are they the same even with the increased weight? I assume you haven’t taken any AI in the last month or so?

Mine actually went from 73 to 49 on the same dose, kind of weird. It took about a year though for it to drop down that much.

#6

My T level didn’t seem to change after I gained weight. Although… It’s hard to notice since it fluctuates with time of blood draw relative to time/date of T injection.

Is your line of though such that weigh gain might have increased demand for T while I didn’t increase T, and thus lowered T slowed conversion to E2?

I haven’t taken any AI for the lady 2.5 months.

Are you talking about T levels ?

#7

More fat usually means more aromatisation, not less. The zinc could be lowering your E2, but it usually doesn’t lower it that much.

#8

No, E2

#9

Yes, so this is similar to my situation. Do you have any idea why that happened in your case?

#10

No clue. My dose went from 180mg/week to 210mg/week too… and it still went down somehow. And my body fat has probably gone up if anything, so I’m really not sure how to explain it.