I’m 42. I’m on TRT with HCG and a bit of Cabergoline.
Recently my conversion to E2 suddenly stopped and my E2 stays around 33 (sensitive Labcorp values), which is low for my erections, I need E2 around 40-50. My E2 used to raise at the rate of approximately 12 points per week and I’ve taken Anastrozole when needed.
I didn’t change the TRT protocol, the only thing was that my last Pregnyl bottle was 9 months expired when I started it.
However, recently I’ve discovered that I have methylation issue as well, and after talking to a specialist I started taking:
Folate (around 2,000mg)
Methyl B12 (around 1,000mg)
Active form of B6, Pyridoxine P5P (825mg)
NAC (N-Acetyl Cysteine)
Zinc Picolinate increased from 30mg to 60mg (it has 2mg Copper so Copper increased to 4mg).
I’m aware that I can raise E2 by taking more HCG. But what hay have caused this sudden stop in estradiol conversion?
Are ANY of the above listed supplements known for lowering estradiol conversion?