There’s a medication used off label for ADHD called guanfacine… another one called clonidine. They work on alpha adrenergic receptors instead of beta adrenergic receptors
Unlike stimulants used for adhd these meds actually work by blunting the sympathic nervous system. Similar to beta blockers, but not as cardioprotective
They were developed as anti hypertensives, but don’t work as well as beta blockers for that purpose. Anyhow what people noticed is that is REALLY calmed people down, aside from a few other properties like the regions in the brain they bind to and antagonise alpha 2 adrenergic receptors
Some very savy people thought of the idea to trial and patent these meds for ADHD (i’m sure they got very rich)
I take them for my terrible ADHD as I prefer them to stimulants that I very seldom use… every time the dose was increased by ONE MILLIGRAM I’d wind up sleeping 12+ straight hours a day for a good week.
It works great if you can get past the first month or two of initiation and dose titration. Many can’t due to work/life, but in high school outside of homework and whatnot you can get away with needing to sleep a lot. Kids going through growth spurts do it all the time
I’m sorry to hear about the LVEF, is that the measurement you’ve had ever since the heart attack?
Is it symptomatically low? I’m not a cardiologist but I know 40% is right on the cutoff between mildly and moderately reduced cardiac function. Mildly reduced is 41-50%
I don’t have heart failure but I have IST. So my heart feels like it’s going to explode if I don’t take beta blockers or ivabradine. Ivabradine us crazy expensive though.
What’s interesting for IST is, beta blockers for a majority of this cohort actually increases energy and exercise tolerance (myself included).
POTS (don’t have this) is even worse because these people faint whenever they stand up without medication and they have can at times have IST in conjunction with that (dysautonomia is a spectrum).
I’d feel better and have more energy on 50-100mg metoprolol per day as opposed to not being on it. Isn’t that interesting?
Many people with IST are found to have antibodies attacking cardiac beta adrenergic receptors so the condition may be autoimmune. Whether a condition increases morality rates long term is unknown. Untreated I think it would as tachycardia induced cardiomyopathy is a real condition.
As to you using steroids in your 20’s, I wouldn’t worry about it. Not a doctor, but from what i’ve noted the body can tolerate a lot of abuse (for most), esp when young.
You are well spoken and highly intelligent. If it had any impact on your IQ I’d think said impact would be very minimal.
But dementia is awful if you have it, my grandma who lives with us is now moderate stage alzheimers. I hate her as a person and always have (view harboured by a lot of my family as she is likely on the spectrum and harbours many narcissistic atrributes).
The denial is the worst. She’s still driving, but only very short trips even though she can’t remember what happened one hour ago and will never give that up even though her executive functioning/processing skills are pretty much gone at this point.
I imagine she will get in a crash relatively soon if her geriatrician doesn’t revoke her right to drive. She wouldn’t listen anyway, a stubborn narcissist will never listen.
It’s like that south park episode
Because her driving skills are shocking. I think even she’s realised now as I don’t see her drive more than 2-3x per week now.
I imagine the way I react to any titration of guanfacine is how most people on beta blockers feel… that… must… suck…