T Nation

Statins, a Help or a Hinderance for Sexual Function

OK, I’m on trt for 4 years,statins even longer, rosuvastatin and after 3 years of trt the treatment seems to have stopped working as well as it used to… I know stains reduce cholesterol and cholesterol is liked to T production… so could the statin be adding to or even be the cause of my low libido and ed or am I barking up the wrong tree??

The usual side effect from statins Is muscle pain or aching. I haven’t heard anyone claim ED from statin before, im sure its possible though. Is it a possible side effect listed?

“Sexual difficulties” is the exact phrase used…
Just trying to get to the bottom of my issues… I’m investigating everything

You need to get labs done to see what is going on.

Where are you located:

The problem might be:
statins causing C0Q10 deficiency
low thyroid function or iodine deficiency

Try to find 50-100mg ubiquinol form of CoQ10 supplement. Do not purchase ubiquinone. If you feel better, there is your diagnosis. If you have a persistent low level cough, that is a sign of low CoQ10 and ubiquinol can fix that. Any muscle pains or weakness?

Have you been using iodized salt or are you iodine deficient. History please.

Please read the stickies found here: About the T Replacement Category

  • advice for new guys - need more info about you
  • things that damage your hormones
  • protocol for injections
  • finding a TRT doc

Evaluate your overall thyroid function by checking oral body temperatures as per the thyroid basics sticky. Thyroid hormone fT3 is what gets the job done and it regulates mitochondrial activity, the source of ATP which is the universal currency of cellular energy. This is part of the body’s temperature control loop. This can get messed up if you are iodine deficient. In many countries, you need to be using iodized salt. Other countries add iodine to dairy or bread.

KSman is simply a regular member on this site. Nothing more other than highly active.

I can be a bit abrupt in my replies and recommendations. I have a lot of ground to cover as this forum has become much more active in the last two years. I can’t follow threads that go deep over time. You need to respond to all of my points and requests as soon as possible before you fall off of my radar. The worse problems are guys who ignore issues re thyroid, body temperatures, history of iodized salt. Please do not piss people off saying that lab results are normal, we need lab number and ranges.

The value that you get out of this process and forum depends on your effort and performance. The bulk of your learning is reading/studying the suggested stickies.

Endo took bloods the other day, hope to get results soon

Hi ksman,I’m in Ireland… 10 years ago at 32 developed hypertension and cholesterol from chronic stress
So stressed that it became the norm and I didn’t even realise I was stressed
5 years ago, had very low mood, tired all the time,ED and struggling with life… got tested for T levels, was very low, was using Testogel for about 6months but eventually stopped working,
Then had a pituatry gland test, ultrasound on my testes and bloods and diagnosed with hypogonadism… that was Nov 2013 , I was put on nebido injections,4 a year… about a year ago they too have stopped working ED is back. I’m back with my endo now, I had an injection last Thursday and that was 17 weeks after my previous jab, should be 12, my ED improves near the end of a 12 week cycle, gets even better if I skip my jab but will eventually return… I have lived a very stressful life for the past 10 years and have made massive strides to eliminate that… sorry for the long reply… endo took bloods the other day and will again in 16 weeks

As for the iodine… I have no idea, not sure I’m getting any or if I deficient… will get what you have suggested, will also get thyroid checked out… thanks

Stress can increase reverse thyroid hormone [rT3] which blocks fT3 and creates hypothyroid issues even when fT3 looks optimal. This problem is caused by stress and known as adrenal fatigue. Please see these terms in the thyroid basics sticky:

  • stress
  • illness, infection, inflammation
  • adrenal fatigue
  • Wilson’s book

Iodine deficiency makes things worse.


  • B-complex multi-vits with trace elements including 150mg iodine and 200mcg selenium. Should also list folic acid.
  • fish oil
  • DHEA may be helpful, but perhaps restricted there
  • natural source Vit-E
  • 5000iu Vit-D3, find tiny oil based capsules, take 25,000iu first 5 days, 5000iu thereafter
  • 1000mg Vit-C at bed time
  • zinc-magnesium supplement at bed time, see ZMAin biotest store for a reference. Magnesium is very important for arterial muscle tone as is T.
  • EFA’s: fish oil, nuts, flax seed meal or oil

Low thyroid function reduces burn of blood sugars and cholesterol and triglycerides because mitochondria are regulated by fT3 as part of body’s temperature control loop. But there is more. While fT3 regulates mitochondrial activity, CoQ10 enables mitochondrial activity. Are you starting to see the picture? And mitochondrial also need ample antioxidants to avoid self damaging them selves when antioxidants do not clean up oxygen free radical byproducts.

Provide oral body temperatures. Please proceed as I have problems following threads as they age.

After getting selenium as suggested for a few weeks, get on a stronger iodine supplement for a while and follow oral body temperature changes.

With adrenal fatigue the problem is reduced fT4–>fT3 while fT4–>rT3 increases. There can be a problem when you increase T4 levels as rT3 then increases. More details needed and this can be more of a challenge than TRT and most doctors are really not good or informed about thyroid and iodine issues. Note that thyroid “normal” lab ranges are really quite useless and mislead doctors, mostly because the medical community really does not understand what lab “normal” ranges really mean.

Post all available lab reports, not just T related.

AM cortisol - at 8AM or 1 hour after waking
DHEA-S [not DHEA] another adrenal hormone
homocysteine - detects inflammation of arteries and progress of changes
Vit-D25 - vitamin D status

  • last three tests are sort of useless as these change over 3 months of nebido and thus represent very little.

A lot to digest there, I will post back as soon as I can, thanks again.