Liberals don’t want Venezuelan socialism, they want Canadian or EU socialism.
The left likes big government to get things done, but blue states are net donors to government revenues while red states are net receivers, so the red states are actually more dependent upon the federal government than blue states. Having said that, the cultural divide is more rural v urban than state v state, so a state that leaves would still have plenty of opposition within their own borders.
Many companies that talk like they are American companies are acting in a globalist style. Why would a company that sends jobs to China or India object to having a factory in an independent California? Certain companies would stay in California because it has so many educated workers (unlike some parts of the US) and respects intellectual property rights (unlike China).
Trump’s trade war with China has annoyed a lot of business minded people, so we can’t assume that businesses would be loyal to a nation remade in Trump’s image. Corporations have no loyalties. A corporation would decide which is worse for the bottom line, that is all.
The Brexit situation is politically different, but it does illustrate the importance of how economically entangled different locations can be; the longer they argued, the more obvious the negative economic consequences became. It has taken two years for PM May to haggle a Brexit deal and it might sink her government. Any deal between California and DC would be even more complicated.
So in the end, I think all the talk about states leaving the union is just shout therapy for the ideologically frustrated.