T Nation

Started TRT 6 Months Ago. Lot of Side Effects


They are small caps full of white powder. You can’t cut them but you could open and remove ~1/2
If you get a pill cutter Walgreens sells them cutting into 1/4 is a lot easier. IMO 1/2mg is too much. I would never take more than .25/wk even if I was blasting.
Some have had luck crushing the pills into a powder and mixing with vodka I’ve never done it and I don’t know the details.


Thanks. I dont think capsules should be cut. Better to open and empty them if needed. Yeah, 1/2mg might be too much. So, if the doctor does put me on AI, I’d like to start with .125mg twice a week as well.


Ya you can twist it open and split or whatever.


UPDATE - just had my consult with Defy Medical. Here are the adjustments:

They switched me to cream and we’d have a follow-up in 4 weeks:

  1. Testosterone 20% cream. 2 clicks to start with. Upto 3 clicks. Didn’t say need to apply on scrotum but if I wanted to, they said, half of one click would be sufficient for scrotum and the remaining to be applied over body - shoulder, chest, waist whatever.
    (While my T on injection is fine, good number, they said, my DHT is in lower half and cream should help increase it - that should help with libido; and they said that because I am naturally low SHBG, daily application of cream is preferable to twice a week shots)

  2. Upped my HCG to 500 IU twice a week (instead of 250 IU twice a week) - should also help with libido.

  3. AI Anastrazole .125mg only if needed
    (they want to keep my e2 between 25 to 35)

So, I’ll be on this protocol for 4 weeks and see how it goes if libido and erections come back.


i wish i had never started HCG with Test when i began TRT


You’ll save tons of money and have better labido and reactions if you only apply to scrotum. Applying to scrotum absorbs 80-90%… the other areas are 10-20%…


I believe that will also increase testicular e2 and Anastrazole does not lower testicular E2. So, I don’t think applying all to scrotum is a wise move.


You don’t know what your talking about my friend . E2 issues are irrelevant with scrotul application. Read the study it’s far superior .


aah, ok. I may have my ideas confused.


I need to get some ball cream.

Wonder if only compounding pharms make it? Or do places like Walgreens etc dispense a brand name of it?


Good question I think it’s compunds and speciality. Regular retail like cvs no.

You need to Make sure it’s quakity and every dose is exact. Men have spoken about inaccurate dosing causing issues.s when they fixed the product they loved it.

Has to be cream not gel because gels got alcohol.


Wonder why big pharma isn’t selling it?


Money … compounded cream isn’t branded so it’s cheap. Go buy androgen and it’s 400$


Click here to read the study


Dude. I can almost guarantee you it is that shitty cream causing a hormonal roller coaster. I started off on testo gels and I got serious anger issues, acne and a tiny gyno in my left nipple from that shit.

Now I’ve been on Nebido injections every 8-9 weeks apart with my through being around 650-700ng/dl and feeling and looking as good as ever. My libido has sky rocketed, hair still looking good at 35, almost zero acne(it’s a genetics thing for me, we get acne and build muscle mass easily).

Man up and go for injections only. I dont even need an AI as my estrogen is smack down in the middleofthe scale of whats normal for a healthy man.


It’s not andro gel or becusse its a cream. Your not understanding what’s being said. It’s being applied to the scrotum… I linked to the article above. There is no roller coaster. Don’t mislead and talk from an uneducated stance on the subject.


Scrotal skin is thin and has high steroid permeability, but the pharmacokinetics of testosterone via the scrotal skin route has not been studied in detail. The aim of this study was to define the pharmacokinetics of testosterone delivered via the scrotal skin route. The study was a single-center, three-phase cross-over pharmacokinetic study of three single doses (12.5, 25, 50 mg) of testosterone cream administered in random sequence on different days with at least 2 days between doses to healthy eugonadal volunteers with endogenous testosterone suppressed by administration of nandrolone decanoate. Serum testosterone, DHT and estradiol concentrations were measured by liquid chromatograpy, mass spectrometry in extracts of serum taken before and for 16 h after administration of each of the three doses of testosterone cream to the scrotal skin. Testosterone administration onto the scrotal skin produced a swift (peak 1.9-2.8 h), dose-dependent (p < 0.0001) increase in serum testosterone with the 25 mg dose maintaining physiological levels for 16 h. Serum DHT displayed a time- (p < 0.0001), but not dose-dependent, increase in concentration reaching a peak concentration of 1.2 ng/mL (4.1 nm) at 4.9 h which was delayed by 2 h after peak serum testosterone. There were no significant changes in serum estradiol over time after testosterone administration. We conclude that testosterone administration to scrotal skin is well tolerated and produces dose-dependent peak serum testosterone concentration with a much lower dose relative to the non-scrotal transdermal route.


Been on cream 3 days. No change to ED. Even with 6x my normal dose of Cialis (from 5mg to 30mg). Erectile Dysfunction is bothering me a lot! Next follow-up is in 4 weeks. So, I guess gotta be patient for a few more weeks.


I am surprised Defy did not put you on both. That is their typical protocol when they want to bump DHT a little. Did you complain about shots?
I’m going to jump out there as predict your 20% T cream will end badly. I do wish you the best but I have seen many posts over the years and only 1 in 20 is successful with creams. I look forward to your blood test if you choose to share them.


We’re you on injections and switched right to cream?


Yeah, was on injections. Defy switched me to cream 4 days ago.
@hrdlvn - I didn’t complain about shots. I did say I prefer less shots, I dont like them. But he commented:
a) your SHBG is low. Better to have daily T. So, I’ll put you on cream.
b) your DHT is lower half of the range. Cream will get you more DHT.