Post Cycle Therapy
Nolvadex uses an enzyme â??CYP2D6â?² to convert itself into a more useful form that our bodies can use. Unfortunately many antidepressants also use this same CYP2D6 enzyme, thus you have two medications competing for the same pathway. The problem? Antidepressants have priority on the CYP2D6 enzyme therefore can render Nolvadex to be nearly useless, which could cause serious side effects during our PCT such as Gynecomastia. If youâ??re on an antidepressant and intend on using Nolvadex as your PCT, itâ??s important for you to know which antidepressants will cause issue and if youâ??re on an antidepressant that will inhibit Nolvadex from being functional, you might want to go with Clomid or Fareston (Toremifene Citrate) instead for your PCT. Below is a list provided showing which SSRI & SNRI are strong to moderate inhibitors and those that are not.
Strong Inhibitors
Generic Names Brand Names:
Bupropion Wellbutrin
Fluoxetine Prozac
Paroxetine Paxil
Quinidine Cardioquin
Moderate Inhibitors
Generic Names Brand Names :
Duloxetine Cymbalta
Sertraline Zoloft
Diphenhydramine Benadryl
Thioridazine Mellaril
Amiodarone Cordarone
Trazodone Desyrel
Cimetidine Tagamet
SSRIs and SNRIs That Are Not Inhibitors
Generic Names Brand Names:
Venlavaxine Effexor
Citalopram Celexa
Escitalopram Lexapro
Some research on another very popular (and newish) SNRI named Pristiq (Desvenlafaxine) itâ??s independent of CYP2D6 enzyme therefore shouldnâ??t negatively interact with Nolvadex.
Hope this helps anyone on SSRIs who is planing a cycle or is already on one.