I’m experimenting with this myself. My TRT was 80mg 2x a week with 0.25mg adex 2x a week, doing 40mg Sun/Mon/WedFri with no AI now. I go in this week to do my bloodwork.
Tough to say. 300 is kinda “no-man’s land” when it comes to AI. Low enough that some won’t need it, but high enough that some will. If you pin 6x a week, I would be kinda surprised if you need any AI. If you get bloods after 6 weeks and have high E2 symptoms, see if you could do maybe 6.25mg asin or 0.25mg adex 1-2x per week. Most seem to prefer asin over adex, but I have read anecdotal stories of hair loss on asin.