With letro, being a jackfuck retard, I have absolutely OBLITERATED my E levels on 1500mg test a week and 50mg/dbol a day.
Thats over 2 grams of heavily aromatizing steroids, and dbols methyl estrogen compounds are especially potent even compared to normal estrogen...and I killed it, horribly.
I was experimenting with trying to completely eliminate water retention on the above ^^^, which was a stupid plan to begin with, and due to incorrect math, I overdosed myself dramatically.
No sex drive, no energy, muscle fullness was flat, joints were barely functional, emotions were fucked.
You get the idea. I was younger, I was stupid, I got cocky.
Its possible, even pretty easy with letro if you get stupid. Even with adex if your an over-responder, it could easily hhappen.