Fertility doctors frequently prescribe Clomid (a SERM), or hCG, or some combination of the two, for patients going off TRT and trying to have kids.
In a recent thread, KSman suggested that combining hCG and SERMs is a bad idea because it jacks up E2 levels. I have a couple questions:
1) Why does this combo of drugs tend to do this?
2) What purpose does a SERM serve for fertility or restoration of endogenous production that would not be accomplished by lowering E2 using an AI?
3) It seems like both SERMs and AIs have the potential to create an E2 rebound if you stop using it. Is this right? If one has more potential to create an E2 rebound, which one is it?
I think the answer to # 1 is: Because hCG because it mimics LH, produces Test, and this aromatizes to E2, especially in the Testes; and because the body cranks out more E2 when E2 receptors are blocked--but I'd like to be sure
Clomid seems to have a track record for restoring pituitary function--it's been used successfully to restart athletes suffering from exercise-induced hypogonadism ("Idiopathic hypogonadotropic hypogonadism in a male runner is reversed by clomiphene citrate ").