Fertility doctors frequently prescribe Clomid (a SERM), or hCG, or some combination of the two, for patients going off TRT and trying to have kids.
In a recent thread, KSman suggested that combining hCG and SERMs is a bad idea because it jacks up E2 levels. I have a couple questions:
- Why does this combo of drugs tend to do this?
- What purpose does a SERM serve for fertility or restoration of endogenous production that would not be accomplished by lowering E2 using an AI?
- It seems like both SERMs and AIs have the potential to create an E2 rebound if you stop using it. Is this right? If one has more potential to create an E2 rebound, which one is it?
I think the answer to # 1 is: Because hCG because it mimics LH, produces Test, and this aromatizes to E2, especially in the Testes; and because the body cranks out more E2 when E2 receptors are blocked–but I’d like to be sure
Clomid seems to have a track record for restoring pituitary function–it’s been used successfully to restart athletes suffering from exercise-induced hypogonadism ("Idiopathic hypogonadotropic hypogonadism in a male runner is reversed by clomiphene citrate ").
[quote]KSman wrote:
hCG needs to be taken for quite a while to allow for recovery and tissue changes. 8 doses is silly. However, a subsequent SERM, it if delivers good LH levels, will provide additional duration.
Do not take high dose SERMs as high LH levels can do the same as high levels of hCG.
Do not ever combine hCG and SERMs together.
High doses of hCG or LH levels that are high, will create high E2 generation inside the testes and anastrozole cannot control that source of E2 in your body. E2 levels can be unmanageable.
No need to combine SERMs.
Take anastrozole while on PCT and then land on 0.5mg/week, if you are a normal responder, and cruise on that to reduced the chances that estrogens will interfere with your HPTA switch over. Anastrozole dose on PCT depends on T levels.
The above is but a sketch.
[/quote]
Thanks,
IS