[QUOTE=Dr. John Crisler;196835]Here’s how you do it:
Start at 12.5mgs Clomid per day. After 3 weeks, run these labs (which you ran before you started, BTW):
TT
LH
FSH
SHBG
E2 (sensitive only)
If you feel much better–the goal of therapy–you are all set. Even if your T levels don’t look great; that would mean you happened to catch your new production level at a trough.
If you don’t feel much better, have your LH and FSH levels risen substantially? If not, increase the dose to 25mgs. A couple weeks later, the same labs again. You can go to 37.5mgs, then 50mg per day if necessary. Notice we are employing 1/4 tab increases, for convenience.
If LH/FSH rose substantially, and T did not, and you still don’t feel well, look to testicular failure as your issue.
Of note, some have gotten great results on only 12.5mgs every other day.
If your T rose nicely, but SHBG also shot up, this counteracts the benefit. The estrogen half of the SERM-class drug did that. Try some Danazol, 50mg per day, oral, to try to lower SHBG.
If E shot up, add anastrazole, starting at 0.25mg every other day, and increase as necessary. Remember, it takes several weeks for E and SHBG to restabilize (SHBG may lower with the E).
Using this protocol can help you avoid going on frank TRT. That would be a good thing.[/QUOTE]