T Nation

Scientists: ACE Inhibitors + Weight Loss

The Article is from Physorg.com

Researchers in Melbourne found that by manipulating fat cells in mice they were able to speed up the animals’ metabolisms.

They found that when a particular enzyme, known as angiotensin converting enzyme (ACE), was removed, mice were able to eat the same amount as other mice but burn more calories and therefore gain less weight.

Animals without the enzyme were on average 20 percent lighter than normal mice and had 50 to 60 percent less body fat, senior researcher at the Howard Florey Institute Michael Mathai said.

“It is very clear that they do have less body fat,” he told AFP.

So are they suggesting that ACE inhibitors should help fat loss? You would have thought that with the widespread use of these drugs someone would have reported weight loss as a side effect by now.

[quote]Colin5989 wrote:
So are they suggesting that ACE inhibitors should help fat loss? You would have thought that with the widespread use of these drugs someone would have reported weight loss as a side effect by now.[/quote]

Bingo.

This is fascinating but I wouldn’t start stocking up on Captopril just yet.


Dr Ian Campbell, medical director of the charity Weight Concern, said the study was “interesting”, but stressed the work had only been carried out in mice.

He also said that although ACE inhibitor drugs were widely used to treat high blood pressure, there was nothing to indicate that, even at high doses, they encouraged weight loss in humans.