I never even tried IM. Used SQ from the start. The pain issue is one I encountered also with sub-q, but I quickly figured out how to fix it. After I inject into the fat, I let the puncture wound seal up, then about 10 minutes later ill rub the site firmly for 10-20 seconds, ill do this another time maybe an hour later and their is no pain the next day. I think the oil is pooling in the fat and causing it to become inflamed, so I think rubbing it moves the oil around so it doesn’t knot up in one spot. I thought it was an allergic reaction because of how bad it hurt and it also made some of the skin in the area red. Maybe I was or am still slightly allergic to the grapeseed oil, but it doesn’t bother me at all anymore.
Be careful about who you tell your doing SQ also. I had an endo go off on me about how it is ONLY IM. But when I asked why, he could not give a solid answer besides “that’s what is says on the instructions”. I had already been successfully doing SQ for a year at that point.
I cant speculate on what it does for estrogen, but I can say that I drove my e2 too low for a long time. So be cautious of that. I think that SQ does help with the e2 spiking.
I have high SHBG, and I would love to do 100mg once a week to drive down my SHBG, but increasing the TT with the larger shot. But I also get the anxiety if my TT goes too high, so I do twice a week.