Of course you can. Mike Tuchscherer has to run a bunch as well, and he just totalled over 2300 in single ply at 275.
Everything else, food, sleep, extra recovery modalities will have to be increased.
Obviously, it's inconvenient, but my take is that if you believe it will sabotage your lifting, it will. If you believe it's not a big deal, you'll work around it fine.
Mind over matter...if you don't mind, it doesn't matter.