T Nation

rosemary enhances the metabolism and removal of endogenous estrogens ?

What do any of you Endocrino/Phisio/Hepatologists think of this ?

Researchers have shown that rosemary enhances the metabolism and removal of endogenous estrogens and decreases their cancer-promoting actions. Researchers evaluated the effects of rosemary extract on the metabolism and action of estradiol and estrone given to female mice. The results of the study showed that feeding female mice a 2% rosemary diet increased liver microsomal oxidation and glucuronidation of estradiol and estrone and inhibited their uterotropic action. (3)

Zhu BT, Loder DP, Cai MX, Ho CT, Huang MT, Conney AH. Dietary administration of an extract from rosemary leaves enhances the liver microsomal metabolism of endogenous estrogens and decreases their uterotropic action in CD-1 mice. Carcinogenesis. 1998 Oct 19:10 1821-7.

Interesting study indeed. Couple of thoughts…I looked up the study and it appears that the increased hepatic metabolism of estradiol was non-specific and therefore the rosemary diet may not only increase estradiol metabolism but metabolism of other hormones as well (Im talkin T here, baby). You see, by increasing gluconidation and hydroxylation reactions you can also increase T metabolism. So if you have impending estradiol related tumor formation then perhaps this would be the priority. If not, then dont wreck your T in an attempt to decrease E2. Also, Im not sure how many readers are ovariectomized female CD-1 mice. Nor am I sure how practical a 2% rosemary diet might be.