[quote]MODOK wrote:
[quote]Lover95 wrote:
Modok:
No homo, but you’re looking very buff in that pic. You’re nipple looks sort of weird though. I think it’s because your pec is so big it’s made your nipple un-circular. Is that why?
I wasn’t recommending accutane, I was recommending retin-a, a topical medication. A topical medication that isn’t designed to be absorbed into the blood stream will almost always be safer than a medication which is absorbed into the bloodstream (antibiotics). If you have acne on you shoulders and your face, and you only use retin-a on your face, you’ll still have acne on your shoulders.
Any use of antibiotics can contribute to antibiotic resistance. In fact, low doses of antibiotics can be worse than high doses, because high doses will kill all bacteria, whereas low doses will allow the bacteria with some antibiotic resistance to survive. Antibiotic resistance is a serious problem, there’s already doomsday mrsa. You’re right, most antibiotics aren’t dangerous to use for most people, but they do cause liver strain. If you drink on antibiotics, that can cause liver damamge.
If you use antibiotics to reduce inflamtion and not kill bacteria, why not just use cortisone? Cortisone will be much more effective at reducing inflamtion, and is safer if it’s used topically. Antibiotics are used to kill bacteria.
I think you thought I was recommending accutane because my post wasn’t clear. Retin-a is less dangerous than antibiotics which are much less dangerous than accutane. Accutane is a very effective treatment, though. It tends to get vilified needlessly.[/quote]
I’m a Pharm.D./PhD in Pharmacology. I know a little about this stuff. There are great reasons for using macrolides for acne vulgaris that are readily available on PubMed or even Google. Corticosteroids due not act upon to inhibit the lipase enzymes that are responsible for the inflammation in acne. Corticoseroids would also retard the healing process of the open dermal wounds that accompany acne. I know you mentioned tretinoin topical, and that is a viable (but more expensive) option. Benzoyl peroxide, macrolide antibiotics (topically or orally) are the standard of care. In addition, macrolide resistance just isn’t a big deal. They aren’t used in the frequency of other antibiotic classes which would develop meaningful antibiotic resistance (such as vancomycin or fluoroquinolones). And we aren’t using them in low doses or short duration with acne vulgaris. These are standard doses for considerable lengths of time. I see no reason why meaningful resistance would happen.
Why are you looking at my nipples?
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I agree with your post although I’m not sure I understand this sentence
In addition, macrolide resistance just isn’t a big deal. They aren’t used in the frequency of other antibiotic classes which would develop meaningful antibiotic resistance (such as vancomycin or fluoroquinolones).
Are you saying that macrolide resistance isn’t a big deal because its not used as frequently as vancomycin? or that it’s not a big deal because it is used frequently, unlike vancomycin? Resistance to vancomycin would be a big deal since it’s the last line of defense against AB resistant drugs and is used very rarely no?
Also, is there a specific macrolide you are referring to? I thought the general mechanism of action for macrolides was to bind to the 50S subunit to block ribosomal translocation, inhibiting protein synthesis