I'm wondering why no one has used recombinant LH and/or rFSH for TRT. From what I understand, both are used in fertility medicine. I understand that hCG is cheaply made from pregnant women's urine, but there have been concerns about hCG. The common concern is some sort of prion disease from urine, even though the urine is sterile.
I think the advantages of using a combination of rLH and rFSH would be precise control of hormone levels, no issues of activating unintended receptors (what's actually in hCG?), and no antibody formation. You could take a blood test for LH and FSH levels, then alter your dose until your LH and FSH levels exactly match those of a healthy young male.
I guess hCG would be fine if FSH is unnecessary to maintain fertility or testicular hormone production, and if a proper hCG dose is known.
Does anyone have information or comments about rLH or rFSH? Specifically, does hCG actually address a lack of FSH in patients, if there's a need for FSH? Also, does hCG activate receptors such as those for prolactin?