Well, I’m 3 months into using the arimidex, needed about 1 mg/week to get into the 20’s. I felt pretty good from a number of standpoints, erections, sex drive, etc., however at some point I began to be unable to sleep on my right side without hip pain. Assumed it would go away, and it didn’t. Assumed hip bursitis, got a cortisone shot, no help. Could be coincidence.
I have scoliosis and a history of back pain, but it has worsened since starting arimidex especially low back. But, it could be coincidence.
And then I developed left hip pain so = both sides. Left hip MRI does show a labral tear, but this is true in many normals. Labral tears can be asymptomatic and my cartilage looks fine. Right hip MRI planned.
Long and short, I’m concerned that arimidex is causing arthralgia and/or joint pain. Could it all be coincidence, yes. Is arthralgia the most common reason why women are non compliant with AI therapy, yes. Although this is not an E2 = 0 situation, there is no literature on arthralgia with E2 = 22. That could mean that’s because it never happens, or not. No studies seem to establish that arthralgia is dose (or more appropriately E2) dependent to my knowledge. Maybe any dose of arimidex can cause this?
I’ve stopped the AI for a few days and instantly E2 = 49 again. Some say there is a rebound effect. So maybe it will lower? That doesn’t sound logical. So, I’m not counting on it.
Other changes I’m trying: switched to subcu for last 2 injections. Holding off on hcg. Wondering if the switch to SC and stopping hcg will get me to a lower place.
I’m seriously hoping it will because I when I have high E2 I get fasiculations. I get all the luck. Completely gone when E2 was controlled, but emerging again now that it’s off. If you do some looking, you’ll find that fasics are in fact correlated with high E2.
Incredible catch-22, forcing me to think about DIM (which seems very poorly evidence based) or other things.