T Nation

Resveratrol- How Much Do We Know?

I’m just curious, it seems we are certain about fish oil, but what about res? Sure it’s worked in mice, but has it actually done anything that has been proven for humans?

People can say those from other countries who divulge in wine more live longer all the want, but who says it’s due to the wine and not just a healthier lifestyle than most americans (not hard to do at all)? Also, if just 1 to 2 glasses a day of red wine is equal to just 2-3mg of resveratrol, why the need for 300mg per serving in the tabs? Is it honestly gona help us live 300 times longer than those who just drink 1-2mg a day? Why not just 100mg a day? Would that prove to have just as good of benefits? Just wanting to know if there’s been any long term evidence on resveratrol. I’ve got a supp for resveratrol right now that supposedly provides 325mg of res per capsule, but I might consider switching to Biotest REZ-V if I can take just 100mg a day and get similar benefits, just cuz I like ordering from Biotest. Thanks for any help.

Just to get this started, one thing I have read about REZ-V is that you need to take the three pills at once to overcome the digestive enzymes in the stomach so sticking to the dosing guidelines is recommended. Anybody else with more knowledge than me want to chime in now?

I haven’t looked at resveratrol studies in a while (November 06 - Jan 07), but I remember some studies using a dosage of basically 1 bottle of REZ-V for a 200 lb person.

I remember the cell culture studies as well limiting apoptosis, but like many things, there is need to go beyond cell cultures, as they are only preliminary.

In 2004 there was a study:

===============================================
HIGH ABSORPTION BUT VERY LOW BIOAVAILABILITY OF ORAL RESVERATROL
IN HUMANS

Thomas Walle, Faye Hsieh, Mark H. DeLegge, John E. Oatis, Jr., and U. Kristina Walle Department of Cell and Molecular Pharmacology and Experimental Therapeutics (T.W., J.E.O., U.K.W.) and Digestive Disease Center (M.H.D.), Medical University of South Carolina, Charleston, South Carolina; and Amgen, Inc., Thousand Oaks, California (F.H.)Received June 7, 2004; accepted August 26, 2004

It stated the following:
“The absorption of a dietary relevant
25-mg oral dose was at least 70%, with peak plasma levels of
resveratrol and metabolites of 491 90 ng/ml (about 2 M) and a
plasma half-life of 9.2 0.6 h. However, only trace amounts of
unchanged resveratrol (<5 ng/ml) could be detected in plasma.
Most of the oral dose was recovered in urine, and liquid chromatography/ mass spectrometry analysis identified three metabolic pathways, i.e., sulfate and glucuronic acid conjugation of the phenolic groups and, interestingly, hydrogenation of the aliphatic double bond, the latter likely produced by the intestinal microflora.
Extremely rapid sulfate conjugation by the intestine/liver appears to be the rate-limiting step in resveratrol�??s bioavailability. Although the systemic bioavailability of resveratrol is very low, accumulation of resveratrol in epithelial cells along the aerodigestive tract and potentially active resveratrol metabolites may still produce cancerpreventive and other effects.”

==========================================

In 2006 we had a paper published by David Sinclair called:

Therapeutic potential the in vivo evidence - Joseph A. Baur and David A. Sinclair

In this paper we can quote the following:
The efficacy of low doses (for example, 200 μg per kg (body weight)daily in a rat model of colon carcinogenesis15) suggests that even the concentration of resveratrol obtained from dietary sources, such as red wine, could be therapeutic in some cases. At higher, but pharmacologically achievable doses, protective effects of resveratrol are more frequently observed, and the results are more dramatic. For example, a daily dose of 40 mg per kg (body weight) increased the survival of mice with subcutaneous neuroblastomas from 0% to 70%16.

In his conclusions in the same paper we can also quote the following:
“In mammals, there is growing evidence that resveratrol can prevent or delay the onset of cancer, heart disease, ischaemic and chemically induced injuries, diabetes, pathological inflammation and viral infection. These effects are observed despite extremely low bioavailability and rapid clearance from the circulation.”

and lastly…

“Moreover, administering a daily dose to a human weighing 75 kg with 100 mg per kg (body weight) of resveratrol would require 2.7 kg of resveratrol a year”

basically 7 grams for a person weighing around 154lbs

Anthony Loera

[quote]CrvtWanabe wrote:
Just to get this started, one thing I have read about REZ-V is that you need to take the three pills at once to overcome the digestive enzymes in the stomach so sticking to the dosing guidelines is recommended. Anybody else with more knowledge than me want to chime in now?[/quote]

interesting you say that. some guy on here talked about how he just used 1 tab a day to prolong how long he has the bottle for, but if your case is true, what he’s doing is of no help?

I dont know about the original poster, but I am not so much interested in the cancer-fighting potential of Res but am interestes as an estrogen blocker.

It has many potential uses, but the big market for resveratol is the potential to possibly increase lifespan by about 20-30%. It has done this on fruit flies and mice. The studies show potential in many life forms.

The dose you need to take is very high and it can get very expensive and was prohibitively expensive until just a year or two ago unless you were very wealthy. The ideal dose would probably cost around 3 grand a year if you found a cheap but reliable source.

The conclusive studies on humans will not be known until we are probably dead due to our lifespan, but much more should be known in a few years. They are also working on creating structures similar but more potent.

www.revgenetics.com/sirtis.htm

I am not taking it yet, but I am watching closely and will make my decision in a couple of years, as much more will be known by then. If I can add another 20 to 30 years of quality life I figure I can wait a year or two to start.

Supposedly it has similar effects to a calorie restricted diet in lab animals. If I could get the effects of calorie restriction and still eat a reasonable amount (ie:way more than 1300- calories a day like the physician testing the theory out on himself) that alone would be worth it

[quote]Tulkastaldo wrote:
Supposedly it has similar effects to a calorie restricted diet in lab animals. If I could get the effects of calorie restriction and still eat a reasonable amount (ie:way more than 1300- calories a day like the physician testing the theory out on himself) that alone would be worth it[/quote]

Exactly both influences the SIRT1 gene, thought to be part of the underlying mechanism by which calorie restriction extends life span. Resveratol is much more potent than wine such as pinoit noir and soon they will have things much more potent than resveratol and more studies to support its effectiveness in humans. Even Berardi has touched on it in the past.