I've been perusing Pubmed for information on resveratrol. I had read somewhere that since resveratrol is structurally similar to diethylstilbestrol, a synthetic estrogen agonist, it also exhibits comparable estrogen agonist activity. Looking at Pubmed articles I see that resveratrol acts as an estrogen agonist or antagonist depending on certain circumstances. It appears that resveratrol will act either as an estrogen agonist or antagonist depending on estrogen receptor isoform (ER alpha vs ER beta) and the presence or absence of
Now I'm wondering what circumstances dictate the presence of 17beta-estradiol and type of estrogen receptor. I guess I'm just looking for information on why resveratrol is always considered strictly an estrogen antagonist, not agonist.