Ofcoarse,the director will have to play a large role in making the movie actually good but Total Recall,A Scanner Darkly,and Blade Runner were all amazing in their own right. Paycheck was forgettable and if done right,im sure Minority Report would have been great.
One idea would to use "The Man in the High Castle" as a story. The idea of an alternate reality of the Axis winning WWII is pretty intresting. I dont think Ive ever seen a film use that idea save for "Jin Roh" (Which would also be awesome if it was live action,not knocking the Anime either because that was probally the best Anime motion picture I ever saw)
A great idea for a film would be "The Forever War" by Joe Hadleman would be absolutely epic but I think the aspect of the government using homosexuality as away to reduce overpopulation would be too controversial.