From a clinical perspective, our study suggests that lifelong endogenous testosterone could have a role in thromboembolism, heart failure, and possibly myocardial infarction, particularly among men. These findings provide another strand of evidence consistent with the cardiovascular warnings about TRT issued by regulators. Further evidence is needed to clarify whether our findings are relevant to the higher rates of these diseases in men than in women,7071 or suggest that agents that lower testosterone would be protective. Additional research is also required comparing the effects of endogenous testosterone with those of exogenous testosterone.
Our study suggests that endogenous testosterone could have a role in thromboembolism, heart failure, and myocardial infarction in men. It might be worth considering whether existing treatments that modulate endogenous testosterone could be used for these conditions.