@ Darkane: Exposure to insulin does not cause type 2 diabetes. It’s largely to do with being overweight:
Fat cells have fewer insulin receptors (the place where insulin binds to open the cell to glucose) than muscle cells.
Fat cells release free fatty acids, and free fatty acids interfere with glucose metabolism.
Excess glucose that canâ??t be used by the cells for energy is stored as body fat, increasing the cellular mass that the pancreas is trying to â??feedâ?? via insulin. In overweight people, insulin production is increased to meet
But there are also other factors that contribute to the disease. Inactive lifestyle is a big one as is heredity.
Also R-ALA is not the best way to go about reducing blood sugar, not that I’m saying it won’t help at all, it’s just that cinnamon extract and 4-hydroxy are better bang for your buck supplements in that regard.
Quick question, I thought those compounds acted in a similar fashion to Insulin, if you have agents other than Insulin doing Insulin’s job, why would the body produce more Insulin as you say?
I’m aware you frequently post sources to journals, do you have one regarding this topic?
Yeah I like to post studies… haha.
Well, you have to consider that I’m taking both things that boost insulin, as well as things that boost the effects of insulin (insulin mimetics).
CH (casein hydrolysate) and Carbs, directly boost pancreatic release of insulin due to the nutrients that are in the blood stream (CH - from the aminos and Carbs). These should be obvious as to how they boost insulin.
4-hydroxyisoleucine works 2 ways. First, it primarily is a glucose disposal agent. Secondly (also) it is said to have a “glucose-dependent insulin-stimulating activity,” which means that it boosts insulin when taken with carbs.
The first means is the most significant. Its ability to sensitize the body to insulin and preferentially get carbohydrates go to muscle tissue versus fat - especially when taken with a carb meal (simliar to how drugs like metformin target type 2 diabetes).
Sure other things like vanadyl sulfate, chromium, and ALA etc were once popular glucose disposal agents, I don’t think they are nearly as effective as 4-hydroxy for this purpose. As far as OTC things go, it’s pretty good, and is somewhat comparable to metformin.
One study I looked examined its “possible extrapancreatic (the pancreas is the normal way insulin is boosted) effect of [4-hydroxy] on insulin signaling and action besides its previously described insulinotropic action…” I’ve looked at several over the years, but the one study I looked at (today) showed that it increases shuttling and use of glucose by muscle tissue (“increase of peripheral glucose utilization rate”) and it decreases the liver’s production of glucose (decreasing hepatic glucose production - aka glucogenesis) which is not what you want to happen around your workout time. Here’s a study for ya http://ajpendo.physiology.org/cgi/content/abstract/287/3/E463
As for ALA, I’m sure you’ve seen the studies on that, and as I mentioned above, it’s also a glucose disposal agent and purportedly has “nutrient partitioning” effects. Most people use it before high carb meals. I’m not convinced however that it is a major benefit. See the following study http://jap.physiology.org/cgi/content/abstract/92/1/50 but of course there are studies to the contrary to those referenced in the receptormax article http://www.tmuscle.com/free_online_article/product_information/special_report_the_all_powerful_supplement
Like I eluded to earlier though some people use glucose disposal agents to drop into ketosis faster, if following a ketogenic diet, but I don’t really like the idea of using these types of things when low-carbing it. As you see above, I use them when I do a targeted ketogenic diet, and only take them with carbs.
Oh, and about cinnamon the receptormax article had some pretty good studies about it. I’ve seen a bunch of good things about cinnamon and nothing bad, so I have no reason to doubt it. This is not the most independent source, but it’s got some interesting info: http://www.cinnulinpf.com/more_info.html Essentially cinnamon (water soluble portion) increases insulin signaling pathways (the ones responsible for improved body composition).