Iodine has been a real bit of serendipity given my shitty health problems. It’s seemed to have had a positive estrogenic effect on me, which according to Dr Wright likely means a decrease of 16a-hydroxyestrone (bad carcinogenic estrogen) in favor of increasing estriol. Previously I had been taking DIM with noticeable results, then added iodine up to 30 mg, and one night I “snapped” into feel much better regarding brain fog, fatigue, and especially mood.
Since then it’s seemed that as the iodine has been saturating my tissues (and came back at 80% saturation according to an iodine loading test a month or so later after this event when I had started to lower the dose) and with it I’m appearing to have “low estrogen” (not just “low estradiol”) symptoms, similar in the past when my DIM dose was too high. Here’s the really interesting thing: I went from 30 mg iodine and 75 mg DIM to 12.5 mg iodine (1 Iodoral tab) and no DIM, and then decided to try adding DIM, and within days noticed slight-moderate hypoglycemia episodes with my glucometer backing me up. So then I got off the DIM and the episodes went away.
But interestingly I’ve remained with a 10-15 point lower average glucose reading, going from low 90s fasting to mid-70s, for example. I’m asking my doc now for an insulin, glucose, and A1C test, seeing how iodine makes you sensitive to potentially all hormones, including insulin, which could mean good news given that I have a family history of type 2 diabetes.
Problem: DIM shifts different estrogenic pathways (increasing 2-hydroxyestrone and possibly 4-OHE as well, the latter being bad), which means DIM and iodine in a sense compete with one another, bringing with it possible changes in symptoms if I used one or the other or both. I’m wanting to get to the point to where I can lower my iodine enough to add DIM again without the hypoglycemia episodes, which I think would help me feel better overall given the upregulation of the 2-OHE pathway.
TL;DR Question: have people here found it to be the case that you start iodine at, say, 12.5-50mg or so and then had to reduce your dose to even below 12.5 mg according to symptoms from your body indicating you’ve pushed through your sweet spot? If so, what iodine dose did you start with and what did you end up reducing it to, and how long did this titration process take before you reached a stable dose?