I have a few estrogen-related questions, and they're more to do with properties of the hormone itself.
In men, E2 is only produced via aromitazation, correct?
How are estrone / estriol produced and why are they unimportant relative to E2?
In men, is measured E2 mostly unbound? I know SHBG can bind to estradiol, but has a much higher affinity for testosterone - when you measure total E2, are you basically measuring bio available E2?
What other hormones can cause sensitivity in the nipples if E2 is under control? Prolactin? Progesterone?