KSman I Have seen on a few of Your post that once intratesticular testosterone levels reach a higher level an AI is ineffective, as I’m a little confused? From my findings an AI should reduce aromatase by large percentage( dose depending ), in other words if 1 mg of arimidex isn’t reducing aromatase,raise dosage accordingly to a level to effectively lower aromatase at the cell or blood serum estrogen levels.
Please understand that I’m not doubting your words or findings, I’m trying to find an understanding of this as it does have me confused as aromatase is in bound in blood.
I have found on a search a study that was on intratesticular aromatase and prostate cancer, though it doesn’t speak of an AI as treatment of effectiveness/ineffectiveness.
Hopefully you can help me get a better understanding on this? Thanks