T Nation

Question About AI Dosage Effect


#1

Hello board. I have a question about AI intake.

I have been taking 30mg of testosterone cypionate 2x/week for about a year now.

I consume 0.25mg (quarter tablet of generic anastrazole) 2x/week as well.

dosage never changed for me.

My regular blood work tests usually results show at about 600-700’s. E2 is usually in the 60’s.

If I were to raise my anastrozole intake from 2x/week to 3x/week, this should lower my estrogen. But would it also raise my testosterone?

I ask this question today because I believe a couple times I had accidentally taken an extra anastrozole dose and my blood work showed my levels to be in the 1200’s.

I never took more testosterone than my dosage.


#2

Increasing the Adex from 0.5 mg/week to 0.75mg/week won’t double your TT levels. Your E2 is too high.


#3

Ok. Thanks Nashtide.

But then I still wonder why my T level shot upwards so much. I never increased my cypionate dosage.

Suddenly one day woke up with mad acne on my jawline and chest, so I got blood tested. Turns out T level was way higher than usual. It’s quite confusing why this happened so just thought I’d ask.

The only thing I could think of was the additional anastrazole.

And my blood tests are monthly.


#4

It would be helpful to know units and ranges.

Post results of other lab work. If your levels are odd, we need to look for other clues.

I missed your post July 2015 :frowning:

Please read the stickies found here: About the T Replacement Category

  • advice for new guys
  • things that damage your hormones
  • protocol for injections
  • finding a TRT doc

You should have tested LH/FSH to try to find the cause.
AST/ALT might have shown some liver issues.
Your thick blood is a root cause.
Avoid iron fortified foods and vitamins.
Thyroid function is a common weakness for guys here, not references to thyroid, iodine and body temperatures in the stickies. Post oral body temperatures

If E2=60 pg/ml <42:
Increase E2 dose by a factor of 60/22 where E2=22pg/ml is the therapeutic target.

Your TT is probably inflated by a lot of SHBG+T [nont bio-available] caused by high SHBG caused by high E2. You need to be concerned with FT or bio-T.

HTC - hematocrit, is creating a limitation for your T dosing.
Donate blood or have removed/dumped and note if you feel better.

Please read this: https://en.wikipedia.org/wiki/Polycythemia_vera
You need to avoid dehydration. You may have headaches.
Take mini aspirin to make blood cells slippery.
Take fish oil which has some blood thinning effects.
TRT can make this condition worse and it seems that TRT brings this problem from a latent susceptibility in some males.
Can affect brain, liver and kidneys.
Also read: https://en.wikipedia.org/wiki/Iron_overload

  • and check ferritin

In cases like this where calculate anastrozole dose seems unreasonably high we need to consider that the liver is not clearing SHBG+T and liver function is suspect. SHBG is made by the liver to scavenge steroid hormones from the blood, which appears to not be working well. Estrogens increase SHBG production and T reduces and a balance occurs from those influences, production and removal. Liver is a key concern and we need to consider that your abnormally thick blood may be part of the issue.

You will need to read up and manage how these issues are investigated. If you overload your doc, she may send you elsewhere.


#5

Thank you KSman. My hematocrit was last shown to be at 19.5 (always between 18.5 and 19.6 every blood test results, since I started TRT). I donate blood every two months. I will post next blood test results as soon as it comes in.

Also, my mental capacity has been feeling quite low the past several months. I hope TRT does not have a long-term effect on the brain. I have not been feeling well mentally, not exaggerating.


#6

Hematocrit is typically in range 40-50%

You appear to have listed Hemoglobin.

Hematocrit is a better measure of overall blood thickness or ability to flow.

About your low mental energy: Have we discussed thyroid and iodine issues before?

  • apparently not!

Are your outer eyebrows sparse?
Have you always used iodized salt and/or vitamins that list iodine+selenium
Check overall thyroid function by taking oral body temperatures as per the thyroid basics sticky. Thyroid hormone fT3 controls cellular energy as part of the body’s temperature control loop.

With TRT, we do see where the increased/restored metabolic demands of T cannot be satisfied by weakened thyroid function or adrenal function.

There is more going on than TRT issues.

Labs:
TSH
fT3
fT4 - please not T3, T4
AM cortisol - at 8AM please