T Nation

Provigil and HOT-ROX

Does anyone know of any reasons not to take modafinil (Provigil) with HOT-ROX? I know there’s a possible interaction with Spike, but I didn’t think to check about provigil.

Thanks in advance.

[quote]nephorm wrote:
Does anyone know of any reasons not to take modafinil (Provigil) with HOT-ROX? I know there’s a possible interaction with Spike, but I didn’t think to check about provigil.

Thanks in advance. [/quote]

I would not use the two concurrently. While the exact mechanisms of action aren’t exactly clear with modafinil, mechanisms with supportive data do include an adrenergic agonism (alpha-1 subtype) as well as a dopaminergic effect. Irrespective of the exact mechanism, the net effect moves me to recommend against concurrent use.