To my knowledge milk thistle is not meant to help while drinking but the days and weeks after, or before. Some recent studies have shown black coffee can aide in reversing the effects of cirrhosis (what you don’t want to happen). Obviously, do your best to not drink shitty beer, higher quality alcohol the better.
In my opinion, and there is alot of controversy here, top shelf vodka is the way to go. Drink a full glass of water for every drink. Try to avoid salty foods, and you may even consider a light calcium supp (Tums) or calcium containing foods throughout the endeavor. These will help neutralize some of the excess stomach acid produced. Eating a high fat meal, even just a peanut butter sandwhich, will help slow the absorbtion, although the effects here are minimal (~10%). Creatine before bed may help with water retention…when your severly dehydrated.
I’m half awake right now, so sorry if this is unclear or hard to read. Bottom line: 4-12 drinks is alot, its hard on your liver, no matter what.