Thanks for the post! A lot f good info. I read that nolva could cause progesterone effects also, but I don't remember where. Could someone post a link to a study or something just to make sure it isn't broknowledge?
That's a good idea with the l-dopa. I'm suprised more people don't take levodopa. It's prordrug to dopamine the way 5-htp is a prodrug to serotonin. It's a prescription medication used for parkinsons (just like prami), but because it's found in plants, it can be sold as a nutritional supplement. It's powerful medication though. With breast cancer serms are used as a first line treatment, then if that doesn't work after a few years, AIs are used as a second line treatment.
With parkinson's, levodopa/carbidopa is used as first line treatment, and drugs like prami, caber, etc. are used as a second line treatment. Levodopa can be almost as effective as pramipexole at lowering progesterone, but with fewer side effects.
Levodopa could be used as a way to pyramid up to prami. Take levodopa at first, and when you can handle more dopamine agonism (a stronger effect, assuming that's what you want), you can start taking prami. Levodopa could also be used the reverse way, to taper off of long term prami use.
The thing about levodopa, is that it needs to be taken with something like carbidopa. Carbidopa is taken with l-dopa, so the l-dopa isn't converted into dopamine outside of the CNS (which can cause side effects). Carbidopa doesn't cross the BBB, so it still allows for the desired levodopa metabolization in the CNS. Carbidopa is presciption only. However, EGCG (green tea extract) can chemically prevent the metabolisation of dopamine (outside the CNS - it doesn't cross the BBB).
With prami, it's already active, so there's no way to selectivly decrease it's dopmaine agonism outside of the CNS. That's part of the reason levo-dopa causes fewer undesirable side effects. So, I would always take an EGCG supplement, which is sometimes called a green tea extract supplement, with l-dopa.
If you want to take levodopa, it'd be a good idea to take it with EGCG, a green tea extract, to help with side effects and to make it safer.
Personally, I would just keep estrogen at the right level, and not take huge doses of progesteronic steroids (other than tren of course), instead of taking prami.