Progesterone Cream Affecting E2 Test Results?

Pharma / TRT Testosterone Replacement
1

I have a question, I recently tested low on Progesterone and Cortisol and I started progesterone cream in 10mg a day before bed to get these up.

These are results before progesterone supplementation:

Cortisol (Serum) [b] 6.6 ug/dL /b - Ref: 6.24-18 ug/dL
Progesterone 0.19 ng/mL - Ref: 0.3 ng/mL (Men age 18-29)

It improved issues with anxiety and helped me sleep a lot better. But now after 1 month I have retested E2 and it shows up as very low.

E2: < 10 pg/mL (before: 25)

I think I overdid the progesterone because my E2 doesn’t show up on the normal test (this is not sensitive test).

I think I screwed my E2 test up also because I took progesterone before bed day before test in morning. I also took more then usual because leak from bottle.

However I do not feel much symptoms of low E and I have felt ok. I had low E from AI use before and this is not same feeling. Obviously I am stopping progesterone now.

Anyone know if Progesterone cream 8-12 hours before E2 test can scew the test results lowering E2 to much?

2

E2 and progesterone should not affect each other’s lab results.

Are you on TRT or natural?
Progesterone could be lowering LH/FSH and thus E2.

3

Hi KSman, for my own knowledge, what effect does Progesterone have on LH/FSH. If one is not on TRT, would supplementing with Progesterone shutdown the HPTA? I can’t seem to find an answer to that question. Thanks

4

Taking this back to your original thread to keep the story intact.