Hi there, I am new to this forum and I am looking for some input from you guys. I have read some posts on here and it would seem that a lot of people like and use prohormones. I have read articles written by very knowledgeable people that state prohormones do less than NOTHING. I am going to post this article here for all to read and I welcome your discussion.
here it is:
NUTRITION AND ERGOGENIC AIDS - QUESTION AND ANSWER ~ PART 2
By Ted Lambrinides, PhD
Andro Update: Androstenedione was featured in issue #5 of Hard Training. At that point in time no research had been performed on young healthy individuals undergoing a strength-training program. The June 2nd issue of the Journal of the American Medical Association featured a study entitled “Effect of Oral Androstenedione on Serum Testosterone and Adaptations to Resistance Training in Young Men.” The purpose of this study was to determine if short and long-term oral androstenedione supplementation in men increases serum testosterone levels and skeletal muscle fiber size and strength and to examine its effect on blood lipids and markers of liver function. Twenty subjects performed 8 weeks of whole-body strength training. During weeks 1, 2, 4, 5, 7, and 8, the men were randomized to either androstenedione (300 mg/day) or placebo. Also, the effect of a single 100 mg androstenedione dose on serum testosterone and estrogen concentration was determined in 10 men.
Serum free and total testosterone concentrations were not affected by short or long term androstenedione administration. Estrogen levels were higher in the androstenedione group after 2, 5, and 8 weeks compared with presupplementation values. Strength and increase in the mean cross-sectional area of Type II muscle fibers increased similarly in the placebo and androstenedione groups. The significant increases in lean body mass and decreases in fat mass were also not different in the androstenedione group, the serum high-density lipoprotein cholesterol concentration was reduced after 2 weeks and remained low after 5 and 8 weeks of training and supplementation. The effect of a single 100 mg androstenedione dose did not affect the serum concentrations of either free or total testosterone.
The authors concluded that androstenedione administration during resistance training did not significantly alter the serum testosterone concentration in normotestosterogenic young men. The increased size and strength observed with resistance training were also not augmented with androstenedione administration. The use of androstenedione increased serum concentrations of estradiol and estrone, suggesting an increased aromatization (aromatization is the conversion of an androgen to an estrogen) of the ingested androstenedione and/or testosterone derived from the oral androstenedione. The use of androstenedione was associated with decreased levels of HDL cholesterol. These date provide evidence that androstenedione does not enhance adaptations to resistance training and may result in potentially serious adverse health consequences in young men.
A couple of other interesting findings from this study were that LH (lutenizing hormone) and FSH (follicular stimulating hormone) were unaffected by supplementation and training in either androstenedione or placebo groups.
This is interesting because the androstenedione supplement utilized during the study was Andro 6 by EAS. This supplement not only contains androstenedione but also tribulus terrestris, which is supposed to increase LH levels, chrysin, which is supposed to inhibit the conversion of testosterone to estrogen, and indole-3-carbinol, which is supposed to help the clearance of estrogen. It is apparent from this study that these additional compounds did not do what they were supposed to do.
King, D.S., et al. Effect of Oral Androstenedione on Serum Testosterone and Adaptations to Resistance Training in Young Men: A Randomized Controlled Trial. Journal of the American Medical Association. Vol. 281 No. 21, June 2, 1999.
INPUT? FROM ANYBODY?