You work from HOME and you SIT. why?
Do you work from a laptop or do you need to use a desktop?
I, too, am stuck in front of my computer all day... I've been experimenting with postures. Standing is good. Lying down is good (cobra pose - but prop yourself up on your elbows and you can type ok. Wonderful antidote to kyphosis).
Seiza (japanese style)
So many different ways to sit...
I try and spend as much time on the floor as possible. Getting up off the floor and getting down onto the floor... Keeps me mobile and comfortable. Something you only really appreciate it if you come to lose it.
I think part of the problem is that when I get suitably engrossed in my work I stop moving about. Then after an hour or so I become aware I'm locked into position.
I've started on less comfortable postures when I do bits I don't need as much focus for (e.g., fiddling with references? Lets sit in an external hip rotation pose). I find lying cobra a wonderful position to risk getting locked in (e.g., for creative work) because it is the only pose I know for working in throacic extension.