Here’s my thread on this from a couple of months ago.
I’ve actually found it to be MUCH harder to get many powders to hold in a pure alcohol solution (this is the word you’re looking for, btw), and the alcohol I’ve been trying to use is 192 proof, believe it or not.
The recipe text posted at the top of the page leaves out some pretty important details. After some experimentation, I have found that PEG does, indeed, make creating a solution far easier than alcohol alone. The main thing is to combine the PEG and powder first, before adding the alcohol.
I had major trouble with nolva, and then last night, incidentally, I tried making it using PEG 600. The recipe states that the nolva is supposed to dissolve in the PEG first, but that was not happening at all. Eventually, I just said what the hell and added my alcohol. Addition of the alcohol at this stage caused the powder to dissolve immediately, which is quite different from what happened before, which is that I had to apply so much heat that I was boiling and evaporating my alcohol.
The solution appears to be far more stable now, and I am further encouraged by the fact that last night was quite chilly, chilly enough to solidify my PEG-600. Colder temperatures are a sure-fire way to get unstable solutions to crash. Well, my nolva still looks perfectly clear and I am pretty happy about it.
I had even more trouble getting letrozole to do anything. Indeed, I couldn’t even get it to dissolve once at 1mg/ml. So this will be my next experiment.
Now, these solutions are still emetic, but you can mix with grapefruit juice or whatever and it completely masks the taste. However, pharmaceutical companies create cough medicine suspensions that are not bad at all using absolutely no alcohol, only other solvents. Which has me thinking about how to do this. I’ve been doing quite a bit of research into this, and I have some ideas, but I’m not going to share them at this point until I get someone to help me out and lead me a bit further down the path. I will say that the new ideas I have involve solvents not discussed here or on any thread I can find about making liquid orals. Everyone seems to think you must use alcohol, but I’m certain there’s a better, tastier method out there.