[quote]David Barr wrote:
So even with highly elevated CHO based meals you would recommend against the supplementation of ALA or are you just talking about the post-workout window?
I inadvertently destroyed the idea of the post-workout window here: http://www.T-Nation.com/readTopic.do?id=659666
But if it existed, ALA doesn’t do anything that we’d want during that period. The fact that it may hinder protein synthesis and glycogen storage suggests the opposite.
Now I follow you regarding not supplementing with ALA when no carbohydrates are present but surely PWO when we do have CHOs present we would want to activate receptors to improve uptake and avoid fat storage.
The CHO should activate the insulin receptors to the extent that is desired, but it’s hard to comment much about that (because we don’t have the details yet).
As far as avoiding fat storage, from carbs, ALA stimulates the insulin receptor and glucose uptake into fat cells, which contradicts our goal.
It seems that there is a misunderstanding that ALA only works on muscle cells.
With regards to the fat cell uptake, again, especially in the post-workout window our depleted glycogen stores are seeking replenishment and would more actively uptake the glucose into the muscle cell rather than the fat one.
Naturally, yes. But with ALA in the picture, indiscriminately activating insulin receptors and storing glucose, that changes things.
As in the Barrticle, I’m not trying to say that ALA is “bad” or makes people fat. We simply don’t have all of the information available to make the kind of conclusions that people (and marketing) are making. In fact, most ideas seem to be contradicted.
Good questions, and I agree about the interesting discussion.
Well interesting information indeed. I will admit that the majority of my research done on R-ALA focused on diabetics and controlled testing on rats. One more question then Dave, when you are discussing ALA, do you mean R-ALA or regular ALA. The reason I ask is because in a lot of the literature I’ve found, S-ALA was the nomer that inhibited glycogen uptake into the muscles.
I just want to make sure we’re talking about the same thing.