This is my first post. I wanted to see what you all would think about my case since there is so much expertise on this forum. I am pretty desperate so I am willing to try anything.
Before I give you my stats and my blood work, the most important thing to note is that I have had Post Finasteride Syndrome for 3 years now (symptoms below). Before that, I took Finasteride 1.25 mg/day for hair loss for 8 years.
I haven’t been to an endocrinologist yet because most endos still dismiss PFS from what I have heard.
The gist of my blood work is that I have low DHT and high Free T and Progesterone (interestingly, both of these are used to form metabolites through the action of 5a-reductase, which is the same enzyme targeted by Finasteride).
The main current theory of PFS is that an epigenetic change is triggered, permanently shutting down gene expression, following changing androgen levels at the backdrop of upregulated androgen receptors from finasteride use.
Stats + Lifestyle:
Weight: 65 kg
Height: 187 cm
Body fat: Very low
Body type: Slim, Toned
Hair loss: Early stage + Accelerating since stopping Finasteride
Exercise: None (severe joint pain)
Diet: High protein
Complete absence of libido
No nocturnal, morning or spontaneous erections
Low penis sensitivity
Weak, pleasureless orgasms
Shrunken (atrophied) penis, scrotum and testicles
More prominent veins on penis
Anhedonia, lack of motivation, depression, apathy
Skin drier than before (less acne)
Dry hair (straw looking)
Urinary problems - urinary incontinence, reduced flow
Severe joint pain - all joints but mostly hip and knees
|Testosteron free||29.27*||pg/ml||7.0 - 22.7|
|17 - OH progesterone||1.17||ng/ml||<1.39|
|Androstanediol-glucuronide||419||ng/dl||168 - 3530|
|Pregnenolone-17-Hydroxy||292||ng/dl||30.0 - 350|
|Prolactin||107.3||mIU/L||M 86 - 324|
|LH||4.3||mIU/ml||М 1.7 - 8.6|
|FSH||2.5||mIU/ml||M 1.5 - 12.4|
|Testosterone||21.45||nmol/l||9.90 - 27.80|
|DHEA-S||149.4||µg/dl||88,9 - 427|
|Estradiol||80.41||pmol/l||41.40 - 159.00|
|Androstenedione||7.70||nmol/l||М 2.1 - 10.8|
|FT 3 (Free Т3)||4.6||pmol/l||3.20 - 6.80|
|FT 4 (Free Т4)||14.37||pmol/l||12.00 - 22.00|
|TSH||1.26||mIU/l||0.300 - 4.200|
I would really appreciate everyone’s opinion what I should do.
Thanks for reading!