T Nation

Post Finasteride Syndrome and Supplements

My DHT is off the charts high. Do you know if all 5 alpha reductase inhibitors put you at risk of Post Finasteride Syndrome (PST)?

I ask because I want to lower my DHT, but do not want to risk the (albeit small) chance of becoming a PST horror story. I know finasteride containing meds are risky, but have even read Saw Palmetto can cause PST?

I am hoping there are some safe supplements – like Pygeum – which may work without risking PST? Any thoughts?

New labs? This is all divorced from your earlier thread and health details, please take this new question there and post new lab data, current protocol etc. DHT is off the charts? Age adjusted or youthful ranges?

My DHT always runs high. From my personal experience and reading recent research it isn’t an issue. Are you concerned?

No. Docs still think that DHT causes prostate enlargement–>cancer. However, all of the research points to estrogens as the problem. And with age and falling T levels, estrogen dominance can occur without abnormal levels of estrogens. DHT used to be available via compounding pharmacies, but the off-shore FDA approved supplier to USA compounding pharmacies was loss with the pre Chinese Olympics crack down on steroid diversions in China and no one has developed a new source. I tried to get DHT compounded, for libido, but there is no option for that now.

Because prostate cancers are androgen sensitive, small minds assumed that the problem are caused by adrogens. But is appears that low T and elevated estrogens are the cause. Compounding this problem is the way that prostate cancer is managed by androgen deprivation. Androgen deprivation causes the prostate to whither, diseased or not. Again an opportunity to think that adrogens are the cause.

Another issue is the lack of sex in many older males. Without ejaculation, seminal fluid does not get evacuated and it gets stale and rancid. There is then inflammation and the action of this inflammation on the prostate is thought to be a cause or contributor. So there is value in TRT to support sexual activity as a prostate health measure. That is way off of the radar for the medical community.

DHT is mission critical for development and maintenance of the sex organs, virilization and mission critical for libido. 5-alpha-reductase inhibitors for hair loss do a lot of damage. The drugs do not cause harm in many cases, low DHT causes harm. But for some, these drugs cause epi-genetic damage to the HPTA and may cause epi-genetic changes to parts of the brain that control libido.

[quote]brentf13 wrote:
My DHT always runs high. From my personal experience and reading recent research it isn’t an issue. Are you concerned? [/quote]Yes, I am concerned because it is disconcerting to see everything close to range, and then one thing so high that it could not be measured! (The test here in Canada just said “somewhere beyond 8600 PMOL/L”.) I am a bit worried about prostate issues and going bald (which seem to be risks for high DHT I see through google), but as I say, it is so high that it is hard to ignore it, although I don’t feel symptoms?

My HRT regimen when I had blood drawn was Test E every 3 days with .25mg Arimidex at the same time. The day before Test inject I injected 250iu hCG. Because my numbers came back slighty high, I have scaled my Test back to 56mg and am having new labs done. I was hoping to add some sort of supplement to reduce DHT too, but I have read horrible things (google Post Finasteride Syndrome) from taking 5 aplha reductase inhibitors.

My last tests are below… I have since marginally lowered my Test dose:
Total T 32.8 [5.8 - 30.4 NMOL/L]
Free T 176.4 [15.6-146 PMOL/L]
E2** 139 [40-161 PMOL/L]
DHT >8600 [860-3406 PMOL/L]
SHBG 23 [10 - 55 NMOL/L]

**E2 is standard assay, not the extra sensitive which is not available in Canada.

[quote]KSMAN
DHT is mission critical for development and maintenance of the sex organs, virilization and mission critical for libido. 5-alpha-reductase inhibitors for hair loss do a lot of damage. The drugs do not cause harm in many cases, low DHT causes harm. But for some, these drugs cause epi-genetic damage to the HPTA and may cause epi-genetic changes to parts of the brain that control libido.[/quote]

Well are there safe DHT suppressors I can use that will not put me at risk of PFS? That is the whole thrust of my thread. (Though I have provided test results and my current protocol since KSman mentioned they would help.)

So I have posted relevant labs and my regimen. Can anyone answer if “there are safe ways of lowering DHT that will not put me at risk of PFS?”

Find something with similar ingredients: http://www.lef.org/Vitamins-Supplements/Item01695/Ultra-Natural-Prostate-with-ApresFlex-and-Standardized-Lignans.html

Read: http://www.lef.org/protocols/male_reproductive/benign_prostatic_hyperplasia_01.htm

Remember, E2 may be more of a risk factor than DHT.

You need to increase AI by: 139/target * 56/old

[quote]KSman wrote:
Another issue is the lack of sex in many older males. Without ejaculation, seminal fluid does not get evacuated and it gets stale and rancid. There is then inflammation and the action of this inflammation on the prostate is thought to be a cause or contributor. So there is value in TRT to support sexual activity as a prostate health measure. That is way off of the radar for the medical community.
[/quote]

Well. Do you have any phone numbers so I can get some help?

I don’t need viagra just find me a woman that makes me horny.

You want to talk to me or phone a hooker?

Well, high DHT can be a big problem for people who have male pattern balding. What would you suggest for them?

[quote]KSman wrote:
You want to talk to me or phone a hooker?[/quote]

What about a three way?

Conference call that is…