[quote]Miserere wrote:
On the heels of the megadosing fish oils thread:
http://www.T-Nation.com/readTopic.do?id=1510159
I went hunting around for info on fats. I found this alarming article which states that polyunsaturated fats (PUFs) promote (not cause) cancer. The main culprit appears to be the omega-6 linoleic acid, but all PUFs are bad in high dosages. This is the article:
How does this fit into the “omega-3s are great” and “PUFs are fantastic” type of publicity that most up-to-date nutritionists are espousing these days?
If PUFs are going to weaken my immune system (the main point I got from the article), I’d rather not be popping fish oil caps by the handful. Is this going to be another fad like the 80s’ no-fat craze? The problem is, if we’re wrong about PUFs, instead of a bunch of fat people (left over from the 80s), we’ll be left with a bunch of cancer patients.
What’s the opinion out there?[/quote]
[quote]Miserere wrote:
On the heels of the mega dosing fish oils thread:
http://www.T-Nation.com/readTopic.do?id=1510159
I went hunting around for info on fats. I found this alarming article which states that polyunsaturated fats (PUFs) promote (not cause) cancer. The main culprit appears to be the omega-6 linoleic acid, but all PUFs are bad in high dosages. This is the article:
How does this fit into the “omega-3s are great” and “PUFs are fantastic” type of publicity that most up-to-date nutritionists are espousing these days?
If PUFs are going to weaken my immune system (the main point I got from the article), I’d rather not be popping fish oil caps by the handful. Is this going to be another fad like the 80s’ no-fat craze? The problem is, if we’re wrong about PUFs, instead of a bunch of fat people (left over from the 80s), we’ll be left with a bunch of cancer patients.
What’s the opinion out there?[/quote]
Fish oil has been proven to weaken immune system in high doses, mainly EPA.
Fish oils and the immune system
OXFORD, UNITED KINGDOM. Animal studies have shown that an increase in fat intake can decrease the number of natural killer (NK) cells found in the blood and spleen. NK cells are an integral part of the natural immune response to virus infections and certain types of cancer. Researchers at Oxford University now report that fish oil significantly decreases NK cell activity in healthy human subjects.
Their clinical trial involved 48 men and women aged 55 to 75 years. The participants were randomized to receive one of six supplements for 12 weeks. The supplements were all provided in the form of capsules, three of which were to be taken with each meal. The nine capsules (daily intake) contained either a total of 2 g alpha-linolenic acid, 770 mg gamma-linolenic acid (from evening primrose oil), 680 mg arachidonic acid, 720 mg docosahexaenoic acid (DHA), 720 mg eicosapentaenoic acid (EPA)+ 280 mg DHA (fish oil) or a placebo (an 80:20 mix of palm and sunflower oils). All the participants had blood samples taken four weeks before start of supplementation, immediately before start of supplementation, and then every four weeks during the trial as well as after a four-week washout period. The researchers found no changes in killer cell activity except in the group taking fish oil. Here they observed an average decline of 20 per cent after 8 weeks and 48 per cent after 12 weeks. The decline was completely reversed after the washout period. The fact that no decline was observed with pure DHA strongly suggests that EPA was responsible. The researchers conclude that an excessive EPA intake could have adverse effects for people at risk of viral infections and some cancers. Editor’s Note: The British researchers’ speculation about fish oils perhaps affecting the effectiveness of NK cells in killing cancer cells is at odds with the results of many other studies. There are at least a dozen studies that show a clear protective effect of fish or fish oil against breast, colon, and prostate cancer. NOTE: This study was partly funded by Unilever. [54 references] Thies, Frank, et al. Dietary supplementation with eicosapentaenoic acid, but not with other long-chain n-3 or n-6 polyunsaturated fatty acids, decreases natural killer cell activity in healthy subjects aged >55 years. American Journal of Clinical Nutrition, Vol. 73, March 2001, pp. 539-48
Main stream medicine does not promote high dose fish oil unless indication based on heart disease. The main problem in society is that the percentage of “good” and “bad” is way off in diets. The real recommendation for society is to add a variety of fish low in heavy metals, and olive oil into diet several times a week, and cut back on the bad fat to get ratio inline.
You should know by now that everything you do is good and bad. Yes it does suck. I take a lot of fish oil and buy it at discount club. I should pay the extra $ and buy Flameout to get more DHA. If enough studies come out to make me change my mind I may cut back.
The root cause of serious chronic diseases such as heart disease, Alzheimer’s disease, cancer, arthritis, and asthma has been identified as chronic inflammation. Fish oil seems to be about the best thing out there for decreasing inflammation. Curcumin is another interesting supplement.
Like I said, you just can not win. If you want to play it safe I think the recommended dose from Flameout has it right for health benefits. Most supplements in very high doses tend to act like drugs, and tend to have strong influences on certain pathways in the bodies. Most, if not all drugs have both positive and negative effects on the body. We can not expect supplements to be different, especially in high doses. It seems that many things that suppress inflammation also decrease the immune system, such as fish oil and curcumin. The very same things that help us the most, may also hurt us in too high of doses.