Personal Experience with HCG Induced Leydig Cell Desensitization

hCG can be damaged if supplied wet. Should be mixed by you. You can use a home pregnancy test and should be positive with 250iu subq EOD. If not positive the hCG is not good.

What were LH/FSH prior to any treatments? You may have been on progressive secondary.

High dose clomid can induce high E2 levels from high T–>E2 inside the testes and anastrozole cannot manage that inside the testes. High dose clomid can create high LH/FSH and high LH can affect the LH receptors just like hCG. 250iu hCG subq EOD is often sufficient. 50mg clomid is a bad dose in almost all cases.

When on clomid, labs should be TT, FT, E2 and LH/FSH. You need to see what LH/FSH levels are to know what you are doing. You can also gain some understanding by reading the HPTA restart sticky.

As for some things your doctor has been doing: Most doctors are very useless at TRT and have shallow understanding and dangerous practices.

I have to question why you are OK injecting hCG but are not injecting T. T is 100% absorbed and least cost. You can inject T subq twice a week with #29 1/2" 0.5ml insulin syringes and dose anastrozole at time of T injections.

More info you need below:


Please read the stickies found here: About the T Replacement Category - #2 by KSman

  • advice for new guys - need more info about you
  • things that damage your hormones
  • protocol for injections
  • finding a TRT doc

Evaluate your overall thyroid function by checking oral body temperatures as per the thyroid basics sticky. Thyroid hormone fT3 is what gets the job done and it regulates mitochondrial activity, the source of ATP which is the universal currency of cellular energy. This is part of the body’s temperature control loop. This can get messed up if you are iodine deficient. In many countries, you need to be using iodized salt. Other countries add iodine to dairy or bread.

KSman is simply a regular member on this site. Nothing more other than highly active.

I can be a bit abrupt in my replies and recommendations. I have a lot of ground to cover as this forum has become much more active in the last two years. I can’t follow threads that go deep over time. You need to respond to all of my points and requests as soon as possible before you fall off of my radar. The worse problems are guys who ignore issues re thyroid, body temperatures, history of iodized salt. Please do not piss people off saying that lab results are normal, we need lab number and ranges.

The value that you get out of this process and forum depends on your effort and performance. The bulk of your learning is reading/studying the suggested stickies.

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