I am a 51 years old man that would like share my personal experience with TRT and hCG.
I will make a complete post later that describes my journey from 2009 until today including detailed bloodwork. Bloodwork in Norway is dirt cheap, like 20 bucks and the result are ready the next day.
That’s a long story including long term Novedex XT (Caspari Nutrition) and Arimidex usage (years).
No doubt in my mind that suppressed E2 for years caused a lot of floaters in both my eyes.
I have used Maca, Horney Goat Weed, Icadiin, l-Arginine, Cialis (2,5 mg ed) etc. etc. for years.
It started back in 2009 with low sex drive, sluggish erections and low energy.
Bloodwork showed test at 620 ng/dL and a little high estradiol, 0.20 nmol/L (0.06 – 0.18). My journey started, back to that later…
The Novedex XT boosted my testosterone to 1100 ng/dL in four weeks.
I dropped the dose from two capsules a day to 1 capsule eod.
The Novedex gave me energy, drive libido and sometimes raging anger…
I continued this from summer 2010 until the product was banned in 2015.
So, when I stopped the Novedex XT my testosterone dropped to 360 ng/dL, so I panicked…
Went to my andrologist, and he suggested a Clomid cycle, but we agreed that I should try arimidex, 1 mg a day. Got bad insomnia and extreme libido after one week, dropped the dose to ½ mg eod.
Continued this regimen until April 2017. Got some joint pain, but dropping the dose to e3d fixed that, Life was great! High libido, energy drive and motivation.
So, in December 2016 my body had stopped responding to Arimidex as it used to, my testosterone was low again, 340 ng/dL Drive, motivation, energy and mood was down. My LH was 7, so maby it was due to lack of vitamins.
One year earlier my LH was 6 and testosterone 580, and I felt great.
Did a lot of traveling in the US (Seattle, San Francisco, New York, Washington DC and Philadelphia) in the beginning of 2017. And to get more testosterone I upped my Arimidex dose, even when my estradiol was only 0.11 nmol/L (0.06 – 0.18).
It worked, extreme libido, mood lifted and I had much more drive.
But the joint pain and itchy dry skin bothered me a lot.
So, in April 2017 it was back to my andrologist.
He again suggested a Clomid cycle but we agreed that I should try Testogel.
I had no idea what I was about to do to my body…
Started with 50 mg testogel ed in April 2017.
WOW, it was magic! Mood, energy, drive, motivation and libido trough the roof!
But two months later, in june 2017 my testicles started to hurt 24/7 and they shrunk fast! The pain was really bothering me, And they pulled up thigh which made it even more uncomfortable.
So, back to my andrologist, and he gave me a prescription for hCG, and in the middle of june 2017 I took my first hCG shot of 500IU. My regimen was 500IU EOD for 1 week (4 shots) then 3 weeks off. It worked wonders with my balls, mood and sex drive, but I was still dependent of 2.5 mg Cialis ed. I addition I took 0.25 – 0.5 arimidex e3d.
Life was great, the hazzle with applying testogel every morning didn’t bother me at The additional 500IU of hCG eod every fourth week (2000 IU total) did wonders.
Then the horror show started!
In November 2017 I traveled with a couple of friends way up north to help them out at their cabin (150 k miles from home, no electricity, no water, no cellular coverage).
I had just taken my last of the four shots of hCG for the month, in fact it was the same morning as I travelled. Well, I remembered to bring Testogel but forgot the Arimidex.
So, one week later I was back home and was bloated, moody, jealous, low sex drive etc. I upped my dose of arimidex to 0.5 mg eod for one week.
I lost 5 pounds of water and was feeling much better one week later.
Then, on the 10th of December at 2 am I woke up and couldn’t fall back asleep, no matter what. My resting heart rate was elevated from 54 bpm to 65 bpm, something was wrong. My body tried to tell me something.
Three days later with almost no sleep I started to panic and went to back to my andrologist for a complete bloodwork (Friday 15th of December). Thinking I still had high estradiol I upped my arimidex dose to 1 mg a day. Well, on the following Monday I experienced anxiety for the first time in my life, and it was horrible, it was like having a large angry animal inside with sharp claws trying to get out.
I was extremely restless, couldn’t sit down even for 5 minutes.
The bloodwork showed normal test 720 ng/dL, and undetectable estradiol, SHIT!
It also showed elevated hematocrit of 55%, and elevated hemoglobin.
I stopped the arimidex but it was too late. I lost 12 punds the next week, extremely dry and itchy skin, looked good though, ripped, sixpack and everything, but I was a complete wreck.
Couldn’t work, had no sex drive, ed, no sleep, in other words I was non functional.
I gave two blood donations (medical) in two weeks, but didn’t feel any better.
Only difference was that my resting pulse dropped, and I couldn’t feel the heart beats anymore lying down.
So, I did a lot of reading and learned a lot about TRT.
I took my hCG one week early to get my estradiol level up again, but I reduced the dose from 500IU eod to 400 IU eod for one week.
NOTHING happened, one week later my testicles started to hurt again, and they felt smaller.
I panicked and started hCG again one week later but reduced the dose once more to 300 IU eod, and reduced the number of shots from four to three.
Still NOTHING, testicle atrophy and pain just continued.
Oh my god, I have fried my testicles, I have ruined my body.
I have desensitized my leydig cells by too much hCG, I’m fucked!
I went into a deep dark hole, the depression, anxiety and hopelessness was extreme!
I wanted to jump off the TRT train, I wanted to get out.
Went back to my andrologist and got a protocol for restart.
I asked him about hcg induced leydig cell desensitization and his answer was, relax, it’s temporary.
He gave me the following regimen:
Four shots of 500 IU hCG e3d for two weeks (four shots).
50 mg Clomid ed for 4 weeks, then 25 mg for three weeks, then 12,5 mg ed for three weeks.
I took the hCG as prescribed together with my usual testogel dose.
One week after the last hCG shot I applied testogel for the last time (Sunday 28th of January 2018). Well, the hCG had absolutely NO EFFECT, I could have used salt water instead.
I knew I was fucked, I would never produce my own testosterone again, my leyding cells was fried by too much hCG. I just wanted to end it all…
My balls had athropied to 50% of their original size and was hurting 24/7, it was uncomfortable to drive car and sit down.
On Tuesday (to days with no testogel) I was a complete wreck, the testosterone withdrawal symptoms combined with extreme depression and anxiety was almost too much for me. I became suicidal. I have never ever experience more extreme fatigue!
I am a 51 year old man with fried testicles and a suppressed HPTA, a restart was useless, but my andrologist was very positive so I continued. The next day was worse, I had to stay home all day.
On Thursday (four days later) I started to feel a little better.
On Friday I woke up at 4 am with a painful rock hard erection.
I stopped the Cialis three weeks ago, WTF? What is happening???
On Saturday I was myself again, no anxiety, no depression, tons of energy and drive.
Made passionate love with my fantastic and supporting wife.
All I take now is 50 mg Clomid ED, and it has been 6 days since I stopped applying testogel and stated the Clomid.
The most fantastic thing of all, my testicles are coming back, they are larger now than one week ago. So from this very recent experience (I have no idea where I will be in 2 weeks or 2 months). But so far I can say that the hCG definitely stopped working, but it seems it had no effect on the body’s own LH signaling hormone.
I feel fantastic now, and will drop the Clomid dose to 25 mg ed tomorrow because I’m afraid to over stimulate my HPTA and testicles.
I will contact my andrologist tomorrow to get his view on the reason I’m back only after 6 days.