Pris, wouldn’t the use of an AI, upregulate the ER, due to there being ultra-low levels of E, leading to increased sensitivity at the receptor?
my understanding is that in down regulation less estrogen receptors are around, making the body more sensitive to the effects of the less estrogen present, where as in up regulation when more estrogen is around more receptors are created, and the overall body response to estrogen - one estrogen molecule is less sensitive.
As Estrogen continues to increase more receptors are created - manufacturing a form of tolerance to the hormone to blunt it’s effects as much as it can. Please tell me if I got it wrong!
or if I am correct… afterall it’s been a few years since I had my head in a book, and you are the one presently in studies…
Well my understanding is that as Less E is created, more receptors are created to compensate - maintaining homeostasis. This would be upregulation and more receptors equals greater sensitivity to estrogen.
So as an example: if you drop E levels (say through use of an AI), you increase E receptors over time. Then, once you stop the AI, and E levels return to normal, the body ‘feels’ the effect of the ‘normal’ E more acutely because there are more receptors.
This is similar to the effects of AAS administration in supra-physiological doses. You pump more androgens into the systam, and the body begins to downregulate androgen receptors, ie reduce their number.
Once you stop (and for me, this is the folly of the ‘cold turkey’ approach to recovery, as compared to the taper), you not only have less androgen production, but you have less receptors to bind them. You end up with a ‘double whammy’.
If you taper over a long enough period, the previously super-saturated and downregulated receptors have a chance to upregulate again, i.e. become more numerous. Then, when you stop, you might still be producing less androgens for a time, but at least you have plenty of receptors to bind to the meagre amounts of androgens that you are producing.
Good, thanks for clearing that up for me, I had basis of the theory down, but the upreg down reg part somehow went all backwards on me.