T Nation

Peripheral vs Serum Estradiol

What are the physiological differences between low/normal/high serum (blood) estradiol and low/normal/medium peripheral (intracellular and tissue) estradiol?

For example if someone, with say 25 pg/ml serum estradiol levels, were to regularly take an AI, but also take estradiol pills or cream, such that their serum estradiol stayed balanced at 25 pg/ml. Would this person be totally messed up or would they feel the same as with no drugs? Do AIs effect intracellur aromatase and what are the implications?

I think that would be dependent on receptor site sensitivity and SHBG levels.