Nandrolone interacts with dopamine on a receptor level, reducing dopamine receptor density (D1 and D2 subtypes I believe), alters mRNA expression of dopamine. 19-nors in general also tend to deplete serotonin. Hence the negative impact on mood (nandrolone and n metabolites also act on numerous other neurotransmitters, however those two are the most glaringly obvious causes of N induced behavioral/mood changes.
Using concurrent androgens in general is a type of polypharmacy. Generally it’s best to either A: reduce dose or B: find natural remedies to combat side effects rather than use medication for a solution, however sometimes (for instance I use a low dose of a beta blocker for social anxiety/mild autonomic instability) medication can work wonders, and the absence of side effects one may experience with a medication (such as me and Atenolol) allows one’s body to reach a level of equilibrium where everything’s great
Post TRT I have experimented with additional androgens. I’ve used
Oxandrolone, in total about 5 weeks use, between 12.5-25mg/day (believe it was spiked with something else). Used for 1st 4 wks at 12.5, 5th wk at 25
Nandrolone (phenylpropionate ester), bout 3-4 wks at something like 75-100mg/wk, can’t remember exactly dose. Helped with joint pain tremendously towards end of 2nd week.
1-androsterone: 2 weeks
Have also used high doses of testosterone, up to 250mg/wk, not all of this was done at the same time. I tend to introduce each individual variable independently so I know how I react.
Over the past 1-1/2 years I’ve probably gone up 25-30lbs in LBM (although my weight itself hasn’t fluctuated much. Prior to TRT (with my chronic pain and all) I’d dropped down to 59kg, at about 18-20%+ bodyfat… Was terrible, now I’m 73KG bout 15-16%. Haven’t grown since age 15 (ephysial plates are/have been fused, my medical history is actually quite interesting, what happened to me was just baaaaaadddd luck). Never had any issues from the increased mass.
Reason for my high BF at the moment is due to a recent flare up of my chronic pain, making it very difficult for me to exercise intensely, unfortunately I put on fat very easily.
I’d be happy to take an ace inhibitor for cardioprotective effect. Other drugs I’d be happy to trial are
- metformin (recent trial shows it helps with fibromyalgia… I have this along with some legit joint problems)
- i’ve used Cialis before (had ED with hypogonadism, was given it to trial, I’ve still got some, but it was great for erections, didn’t even need to be aroused)
- methyltestosterone, mestanolone, mesterolone, methenolone and fluoxymesterone are all drugs I wish to take within the next 50 years of my life.
- I wish to compete in bodybuilding, however the chronic pain makes that dream very difficult. I’ve had the dream of stepping on stage since I was about 12. As a kid I’d spent my time watching strongman comps and bodybuilding shows… Which was a bit strange but ehhh. Pumping iron was my fav film at age 9 lol
Lifestyle isn’t terrible, but not great either. I never consume alcohol. Used to on occasion, but I see absolutely no point in drinking. I love the taste of beer, with beer and soda water being my two fav beverages, but they have non alcoholic beer so I can drink that without the toxic effect on my body. (legal age is 18 here, 16 at parties which are private venues, used to be 16 if with an adult eating a meal but law changed on March). I use cannabis socially but don’t touch anything else, the fact that it helps with pain is a huge bonus, esp if I’m at a party where one has to dance and move around a lot. drug use (hard drugs too)/drinking is very rampant among youth in my area (much more so than when I lived in America). Eat fairly healthy, exercise as much as possible (including cardio, both LISS and moderate to high intensity aerobic exercise).
Sleep 9-12 hours a day (I have problems with fatigue, I sleep a loooooooooooooooooooooooooooottttt.
Make sure to get adequate water, vegetable and mineral intake. I have OCD style tendencies with many things, and thus I do tend to meticulously track my intake of vital essentials otherwise I don’t feel right (it’s placebo/in my head, but it irritates me and if it doesn’t harm me then why fix it)
Also have a merck manual and a bunch of other medical books that I sometimes read because i’m a rather strange individual
Furthermore I should add I’m very aware of the risks associated with the use of anabolic steroids. I’m not oblivious to the potential long term effects on my cardiovascular system, potential neurotoxicity, nephro/hepatotoxicity, haematological alterations etc. The doses I use are low, which may somewhat mitigate the risk (or not, who knows).
Feel free to give me backlash regarding my decisions. I don’t mind criticism/ judgement, I’m fully aware my decisions regarding experimentation with androgens aren’t responsible. It’s not that I don’t care or can’t comprehend my own mortality (as appears to be a common trait of many teenagers), it’s that when I weigh out the pros and cons, I don’t see particularly significant risk/ an imbalance between benefit/risk assessment. I view my benefit/risk ratio/assessment based on how much something impacts my quality of life, health and wellbeing, and the potential impact on my longevity. While androgen experimentation certainly doesn’t do any good for my long term health, the impact of low doses (as specified above) on my overall quality of life and general wellbeing is significant, and with the absence of creeping HCT/ other parameters, a clean echocardiogram (both recently and at birth), multiple EKG’s checking out etc I think “ehhhhhhhhh, not too worried”. The neurotoxicity/ cardiovascular toxicity is my biggest worry by far.